WEBVTT 00:00.179 --> 00:07.617 Na batho ba entetsoeng ka theknoloji ea "ente" ea mRNA ke lihloloa tse fetotsoeng liphatsa tsa lefutso? 00:07.617 --> 00:11.843 Ke hobaneng ha ente ena e ka kena lebeseng la letsoele? 00:11.843 --> 00:16.954 Mme ke hobaneng ha tshilafalo ya DNA ka hara meento ena e ka baka mefuta e metjha ya 00:16.954 --> 00:20.988 mofetshe kapa esita le mofetshe o matlafaletseng? 00:20.988 --> 00:26.535 Salang le rona 'me le fumane lenaneong le latelang hore na hobaneng theknoloji ea 00:26.535 --> 00:30.559 "ente" e thehiloeng ho mRNA e kotsi ho batho! 00:30.559 --> 00:36.696 Ka 2019, nakong ya sewa sa coronavirus, ho ile ha sebediswa theknoloji e ntjha ya ente ho batho 00:36.696 --> 00:40.549 ka lekgetlo la pele: theknoloji ya ente ya mRNA. 00:40.549 --> 00:46.510 Le mehleng eo, dingaka di ne di lemositse hore thekenoloji ena e ntjha e tla sebediswa ho etsa teko ya tshebetso 00:46.510 --> 00:52.921 hodima batho bohle, ho sa etswa diphuputso tsa mahlale tse tebileng esale pele ho lekola ditlamorao tsa yona! 00:52.921 --> 00:57.779 Kajeno, hoo e ka bang lilemo tse 'ne ka mor'a ho hlahisoa ha theknoloji ena ea ente, ka bomalimabe hoo e ka 00:57.779 --> 01:03.162 bang litšabo tsohle mabapi le litlamorao tsa theknoloji ena e thehiloeng ho mRNA li phethahetse. 01:03.162 --> 01:11.945 Setsebi sa baeloji ea li-molecule Prof. Dr. Klaus Steger le Prof. Dr. Alexandra Henrion-Caude, setsebi sa lekaleng la RNA le 01:11.945 --> 01:21.038 epigenetics , ba akarelitse liphuputso tsa morao-rao mabapi le theknoloji ea liente e thehiloeng ho mRNA pampitšaneng. 01:21.038 --> 01:27.338 Sehlooho ke: Theknoloji ea 'ente' e thehiloeng ho mRNA: Papali e felile! 01:27.338 --> 01:32.795 Pele re ka u akaretsetsa sena ka bokgutshwanyane, mona ke ditlhaloso tse mmalwa tsa mantswe. 01:32.795 --> 01:38.820 Mokento oa coronavirus oa mRNA ha o sa bitsoa mokento, empa o bitsoa theknoloji ea mokento 01:38.820 --> 01:42.670 e thehiloeng ho modRNA e sebelisoang ho batho. 01:42.670 --> 01:51.608 modRNA, hobane ke mRNA e entsoeng ka boenjiniere ba lefutso e ke keng ea bapisoa le mRNA ea batho 'meleng. 01:51.608 --> 01:58.534 Ho latela setsebi sa baeloji Prof. Dr. Ulrike Kämmerer, ente ea coronavirus ha ea lokela ho bitsoa ente. 01:58.534 --> 02:02.428 Ngaka Kämmerer o boletse tse latelang puisanong: 02:02.428 --> 02:06.425 "Ha se ente ka kutloisiso e tloaelehileng, empa ke mofuta oa boenjiniere ba liphatsa tsa lefutso." 02:06.425 --> 02:10.498 Hape ha se phekolo ea liphatsa tsa lefutso, hobane ha ho letho le phekoloang; ho e-na le 02:10.498 --> 02:13.197 hoo, ke boenjiniere ba liphatsa tsa lefutso. 02:13.197 --> 02:21.611 Ke ts'ebeliso ea boenjiniere ba liphatsa tsa lefutso, 'me le hoja ente ea sebele e kenyelletsa ho enta mookotaba o bolaoeng kapa 02:21.611 --> 02:28.580 karolo ea oona, ke hore, protheine ea mookotaba, 'na ke na le tekanyo e behiloeng e seng e sa khone ho ata 02:28.580 --> 02:36.063 'meleng 'me qetellong e a bolaoa, e siea feela karabelo ea 'mele ea ho itšireletsa, ha re ka rialo. 02:36.063 --> 02:43.703 Empa joale ke qobella lisele tsa batho ho sebetsa joaloka libaktheria tsena mofuteng, e leng hore, ho qala ka ho hlahisa 02:43.703 --> 02:50.127 liente ka botsona ntle le ho tseba hore na li tla sebetsa hakae, hore na li tla tšoarella nako e kae, hore na 02:50.127 --> 02:57.080 mohlomong li tla tšoarella bophelo bohle, kapa hore na li tla kena ka har'a khubu ea sele. 02:57.080 --> 03:03.550 Sena se bolela hore motho e mong le e mong ea amohelang liente tsena, ho kenyeletsoa le liente tsa kamoso, qalong e 03:03.550 --> 03:07.473 tla ba mehloli e fetotsoeng liphatsa tsa lefutso ka likhoka. 03:07.473 --> 03:11.163 Ka tlase ke kakaretso e khuts'oane ea liphetho tsa phuputso. 03:11.163 --> 03:16.913 Theknoloji ea mRNA ka sebopeho sa liente e ka baka tse latelang ho batho: 03:16.913 --> 03:23.982 Ho ruruha ho sa foleng karolong e 'ngoe le e 'ngoe ea 'mele, mohlala, ho ruruha ha mesifa ea pelo le pericardium. 03:23.982 --> 03:28.280 RNA e fetotsoeng e ka kopanngoa le DNA ea lisele tsa batho. 03:28.280 --> 03:35.123 Haeba sena se etsahala liseleng tsa peo tsa bonna kapa tsa botšehali, jenomo ea meloko e tlang e tla fetoloa. 03:35.123 --> 03:42.007 Theknoloji ea ente ea ModRNA kapa ho kenyeletsoa ha ModRNA liseleng tsa 'mele ka boeona ho ka baka mefuta e 03:42.007 --> 03:49.240 mecha ea mofetše, 'me ho batho ba seng ba na le mofetše, ho ka baka mofetše o matlafalitsoeng! 03:49.240 --> 03:55.154 Kla.TV e akaretsitse lintlha tse 'maloa tse tsoang pampitšaneng 'me e li hlahisitse hape mona ka mokhoa o khutsufalitsoeng. 03:55.154 --> 04:02.079 Pampitšana e feletseng e ka fumanoa ka tlas'a lenaneo ka Sejeremane le Senyesemane ka lebokoseng le leputsoa. 04:02.079 --> 04:09.636 1. U bolelloa, "Ke ente," empa seo ha se 'nete. 04:09.636 --> 04:15.336 Ha se "ente" hobane e fihlella litekanyetso tsohle tsa sehlahisoa se fetotsoeng liphatsa tsa lefutso. 04:15.336 --> 04:22.381 E na le mRNA e fetotsoeng e entsoeng ka maiketsetso, modRNA, e phuthetsoeng ka har'a likaroloana tse nyenyane 04:22.381 --> 04:27.735 tsa mafura tse tsamaisang modRNA ka har'a lisele tsa rona. 04:27.735 --> 04:35.176 2. U bolelloa, "Ke mRNA," empa seo ha se 'nete. 04:35.176 --> 04:41.574 Ha se mRNA, empa ke mRNA e fetotsoeng, modRNA. 04:41.574 --> 04:49.770 Leha modRNA ena e entsoeng ka maiketsetso e etsisa mRNA ea tlhaho, e na le litšobotsi tse fapaneng ka ho feletseng: 04:49.770 --> 04:57.342 Ho fapana le mRNA ea tlhaho, e senyehang kapele, modRNA o tsoang ho 'mekento' ea Covid-19 o fumanoe maling nako e ka fihlang ho 04:57.342 --> 05:02.387 matsatsi a 28 le liseleng nako e ka fihlang ho libeke tse robeli. 05:02.387 --> 05:06.946 Ho bontšitsoe hore protheine ea spike e hlahisoang ke mRNA e kentsoeng e ka potoloha maling 05:06.946 --> 05:10.278 nako e ka fihlang likhoeling tse tšeletseng. 05:10.278 --> 05:14.649 DNA e boetse e teng ka har'a liente, e leng ntho e sa lebelloang ho hang. 05:14.649 --> 05:21.572 Ho fumanoe litšila tse ngata tsa DNA meqolong ea liente, 'me litlamorao tsa tsona lia tšoenya 05:21.572 --> 05:26.247 ho latela tsebo ea rona ea saense ea hajoale. 05:26.247 --> 05:32.993 Li ka baka phetoho taolong ea liphatsa tsa lefutso 'me tsa beha kotsi ea ho kena ka har'a liphatsa tsa rona tsa lefutso . 05:32.993 --> 05:41.427 3. U bolelloa: "Mokento o lula mosifeng oa hau," empa seo ha se 'nete. 05:41.427 --> 05:49.695 "Mokento" ha o a ka wa rerelwa ho dula mesifeng, empa e le ho kena maling, ditshikeng tsa lymph le esita le lebeseng la letswele. 05:49.695 --> 05:54.765 Ho fapana le likaroloana tse ling tse ling tsa liente tse tloaelehileng, likaroloana tse 05:54.765 --> 05:58.773 nyenyane tsa mafura tse nang le mRNA ha li lule maling. 05:58.773 --> 06:05.406 Ho e-na le hoo, li ka khona, ka tšimoloho, ho kena seleng e 'ngoe le e 'ngoe 'meleng oa rona, ho kenyeletsa le 06:05.406 --> 06:12.936 litho tsa bohlokoa tse kang pelo, boko, sebete, liphio, matšoafo, lienye, mpa, li-ovary le li-testicle. 06:12.936 --> 06:17.561 Likaroloana tse nyenyane haholo tsa mafura li baka ho ruruha haholo ebile li na le chefo. 06:17.561 --> 06:25.059 Ka hona, liente tse pheta-phetoang li eketsa tšenyo liseleng tsa rona 'me li ka ba lebisa lefung la lisele pele ho nako. 06:25.059 --> 06:31.055 Litla-morao tse mpe tse atisang ho hlaha li kenyeletsa myocarditis le pericarditis, ke hore, 06:31.055 --> 06:35.290 ho ruruha ha pelo, haholoholo ho batho ba bacha. 06:35.290 --> 06:41.468 Ho ruruha hona ho ka etsahala hore ho bakwe ke tlhaselo ya sesole sa mmele se hlaselang disele tsa pelo tse nkileng dikarolwana 06:41.468 --> 06:45.839 tse kentweng ka ente mme tsa bontsha protheine ya spike . 06:45.839 --> 06:55.266 5. U bolelloa hore "mRNA e ke ke ea kopanngoa le DNA," empa seo ha se 'nete. 06:55.266 --> 07:03.469 mRNA e tsoang "mokentong" e ka kopanngoa le DNA, kaha karoloana ea eona e fumanoe liseleng tsa mali tsa bakuli. 07:03.469 --> 07:09.888 Ditsilafatsi tsa DNA tse fumanweng mekento ya mRNA ya BioNTech/Pfizer di na le tatellano ya vaerase ya dikgabo e 07:09.888 --> 07:14.759 kenyeletsang tatellano ya sehlohlelletsi sa Simian Virus 40 (SV40) , e tsejwang ka ho 07:14.759 --> 07:19.028 kgothaletsa phalliso ya DNA ka hare ho ntlha ya sela. 07:19.028 --> 07:26.034 Sena se eketsa kotsi ea hore DNA ena e tsoang kantle e kopanngoe le jenomeng ea lisele tsa rona, ka litlamorao tse sa lebelloang. 07:26.034 --> 07:32.057 Ha e 'ngoe ea liketsahalo tsena e etsahala liseleng tsa peo tsa monna kapa tsa mosali tse amehang ho 07:32.057 --> 07:36.698 nolofatsa, e tla boela e fetole jenomeng ea motho ea morutuoa. 07:36.698 --> 07:43.258 Kopanyo efe kapa efe ea tšebetso ea jenomo ea tatellano e tsoang "mokenteng" e ka 'na ea fella ka ho 07:43.258 --> 07:48.069 hlahisoa ha jini e sele le taolong e sa tloaelehang ea jini. 07:48.069 --> 07:53.243 Sena se ka qetella se lebisitse ho kenngweng tshebetsong ha li-oncogene kapa ho tima ha lijini tse 07:53.243 --> 07:57.366 thibelang lihlahala , tse ka bobeli li khothalletsang kankere. 07:57.366 --> 08:04.129 Kotsi ena e mpefatswa ke ho fokotseha ha sesole sa mmele sa ho itwanela se bonoang ho batho ba bangata ba "entilweng", e leng se 08:04.129 --> 08:08.515 bolelang hore tshireletso ya mmele ha e a lekana kgahlanong le disele tsa mofets'e. 08:08.515 --> 08:13.488 Sephetho e ka ba "mofets'e o potlakileng haholo". 08:13.488 --> 08:19.505 Bahlomphehi, diphuputso tsa mahlale mabapi le theknoloji ya ente ya mRNA e tsheheditseng pampitshana ena di 08:19.505 --> 08:24.198 fumaneha lefatsheng ka bophara mme di ka fihlelleha inthaneteng. 08:24.198 --> 08:29.076 Leha ho le jwalo, balaodi le mecha ya phatlalatso e ka sehloohong ha ba a itokisetsa ho sebetsana le taba ena! 08:29.076 --> 08:34.663 Ka hona, sebedisa dikgokahano tsa hao tsa botho mme o phatlalatsa temoso ena mabapi le thekenoloji ya ente e 08:34.663 --> 08:37.341 theilweng hodima mRNA ka pharalatsa kamoo ho ka kgonehang!