1
00:00:00,134 --> 00:00:08,702
"Kwiintsuku ezintathu emva kokufumana isitofu sam sesithathu
se-COVID-19 ngomhla we-17 kaJanuwari 2022, ndaye ndatyhafa, kwaye

2
00:00:08,702 --> 00:00:17,475
xa ndaphaphama, ndandibhideke ngokupheleleyo kwaye imilenze
yam yayingasakwazi ukundixhasa. Ndingasakwazi nje ukuhamba."

3
00:00:17,475 --> 00:00:24,726
"Kubantu abagonyiweyo, iproteni ye-spike kunye nokudumba
zifunyenwe kumalungu amaninzi emizimba

4
00:00:24,726 --> 00:00:33,364
kwiiveki nakweenyanga emva kokugonywa, nto leyo
ebinxulumene nezifo ezinzima nezisoloko zibulala."

5
00:00:33,364 --> 00:00:43,071
Kodwa le mveliso ingalindelekanga neqhubekayo
yeprotheyini efunyenwe kwi-mRNA ingacaciswa njani?

6
00:00:43,071 --> 00:00:50,390
Ekupheleni kuka-2023, i-Kla.TV ipapashe ileta
engxamisekileyo kaNjingalwazi Gqr. Sucharit Bhakdi

7
00:00:50,390 --> 00:00:54,729
"ngeengozi ezingapheliyo zezitofu ze-RNA" ngeelwimi ezininzi.

8
00:00:54,729 --> 00:00:55,806


9
00:00:55,806 --> 00:01:02,714
Ngoku, ekupheleni kukaMatshi 2024, uNjing. Gqr. Sucharit Bhakdi,
uNjing. Karina Reiss kunye noGqr. Michael

10
00:01:02,714 --> 00:01:10,104
Palmer bapapashe inqaku apho iziphumo ezitsha
ziqinisekisa zonke izilumkiso ezenziwa ngelo xesha.

11
00:01:10,104 --> 00:01:14,394
Bachaza ngendlela yenzululwazi echanekileyo, kodwa ngendlela
eqondakala lula ngabantu abaqhelekileyo,

12
00:01:14,394 --> 00:01:19,357
ukuba kutheni izitofu zokugonya ezibizwa ngokuba
yi-mRNA zibubuxoki kwaye ziyingozi kakhulu.

13
00:01:19,357 --> 00:01:28,197
Eli nqaku liphandwe kakuhle lilungele ukwabelwana
ngalo nabani na ongakhange ayiphande le ngongoma nzulu.

14
00:01:28,197 --> 00:01:32,724
Inokufunyanwa njengefayile ye-PDF
phantsi kwale nkqubo ukuze iprintwe.

15
00:01:32,724 --> 00:01:37,865
Ngezantsi, uNjing. Bhakdi uyakufundela eli nqaku phezulu.

16
00:01:37,865 --> 00:01:47,615
Impembelelo ebonakalayo yeemeko ezichazwe nguNjingalwazi Bhakdi
kwabo sele benzakele iboniswa kwingxelo elandelayo kaLara.

17
00:01:47,615 --> 00:01:53,399
Ungomnye wamaxhoba amaninzi okugonywa nge-coronavirus kwaye
ubalisa ibali lakhe lobuhlungu kwi-symposium

18
00:01:53,399 --> 00:02:00,849
yabezindaba ye-MWGFD enesihloko esithi "Ugonyiwe,
wonzakaliswe, wakhanyelwa... kwaye ngoku yintoni?" Prof.

19
00:02:04,268 --> 00:02:13,410
Zihlobo ezithandekayo zoluntu. Sithandwa sisazisi somntu,
ndinento ebaluleke kakhulu, kakhulu endifuna ukunixelela yona.

20
00:02:13,410 --> 00:02:21,539
Imalunga nokufunyanwa kweDNA kutshanje kwizitofu zokugonya.

21
00:02:21,539 --> 00:02:30,580
Isizathu sokuba izitofu zokugonya ze-RNA zibubuxoki
kwaye ziyingozi kakhulu ngoku sisihloko esixoxwayo.

22
00:02:30,580 --> 00:02:38,860
Iikhromosom ziziincwadi zobomi, ezineeresiphi
ezikhowudwe kwi-DNA zokuveliswa kweemolekyuli zeprotheyini.

23
00:02:38,860 --> 00:02:46,095
Ukuba kuyimfuneko, kuvulwa incwadi
efanelekileyo kwaye kwenziwe ikopi yeresiphi efunwayo.

24
00:02:46,095 --> 00:02:50,009
Le kopi yi-mRNA.

25
00:02:50,009 --> 00:02:55,858
Ilawula imveliso yeprotheyini ize emva koko ilahlwe.

26
00:02:55,858 --> 00:03:05,006
Izijovo ze-RNA ziyafana nezi khopi zingahlali ixesha lide
zeeresiphi zeekhromosom; kodwa ngokungafaniyo nazo,

27
00:03:05,006 --> 00:03:10,841
zibangela ukuveliswa kweeprotheyini ezingekho kwimizimba yethu.

28
00:03:10,841 --> 00:03:21,662
Endaweni yoko, zibangela ukwenziwa kwee-antigens
ezingezizo, ezifana ne-spike protein ye-SARS-CoV-2.

29
00:03:21,662 --> 00:03:30,371
Ugonyo ngalunye lolu hlobo lunika iikopi
ezingaphezu kwebhiliyoni (iimolekyuli ze-mRNA).

30
00:03:30,371 --> 00:03:39,220
Ukuveliswa ngobuninzi kwesitofu se-mRNA
kufuna ukufumaneka ngobuninzi kweresiphi ye-DNA.

31
00:03:39,220 --> 00:03:41,439
Oku kunokufezekiswa njani?

32
00:03:41,439 --> 00:03:47,162
Indlela esetyenziselwe ukusombulula le ngxaki
isisiseko esibalulekileyo sobunjineli bemfuza.

33
00:03:47,162 --> 00:03:54,197
Iibhiliyoni neetiriliyoni zeekopi
zeeresiphi ze-DNA zivela kwiibhaktheriya.

34
00:03:54,197 --> 00:04:01,605
Iiresiphi zifumaneka kwiikhromosom ezincinci
zebhaktheriya ezibizwa ngokuba zii-plasmids.

35
00:04:01,605 --> 00:04:07,312
Iiseli zebhaktheriya zinokwahlukana qho emva
kwemizuzu engama-20, nto leyo ethetha ukuba inani

36
00:04:07,312 --> 00:04:10,940
leeseli liyanda ngokuphindwe kasibhozo ngeyure nganye.

37
00:04:10,940 --> 00:04:17,495
Ngale ndlela, iibhaktheriya ezingenakubalwa zinokuvunwa
kwinkcubeko elulwelo kwiintsuku nje

38
00:04:17,495 --> 00:04:25,215
ezimbalwa, kwaye iseli nganye yebhaktheriya iya kuba
neekopi ezininzi zeplasmid ekuthethwa ngayo.

39
00:04:25,215 --> 00:04:27,988
Iiplasmidi kulula ukuzilawula.

40
00:04:27,988 --> 00:04:35,860
Iirekhiphithi zangaphandle, oko kukuthi, iijini
ezikhowuda iiproteni zentsholongwane, umzekelo, zinokufakwa.

41
00:04:35,860 --> 00:04:47,639
Emva kokuzala kweebhaktheriya, iiplazmidi ziyavunwa zize
zisetyenziswe njengamatemplate ekwenzeni iikopi ze-mRNA.

42
00:04:47,639 --> 00:04:56,007
Ekugqibeleni, iimolekyuli ze-RNA zifakwa kwiigolibhu ezincinci
zamafutha ezibizwa ngokuba zii-lipid nanoparticles (LNPs).

43
00:04:56,007 --> 00:05:04,729
Iinxalenye eziphambili ze-LNP zenziwa
ngokwenziwa kwaye zaziwa ngokuba yityhefu ngokwazo.

44
00:05:04,729 --> 00:05:12,408
Ngaphezu koko, izidibanisi ezikhethekileyo ze-lipid
ezisetyenziswa yi-Pfizer/BioNTech ne-Moderna bezingekavavanywa

45
00:05:12,408 --> 00:05:20,413
nakubantu phambi kokuba izitofu zokugonya ze-mRNA
ezivela kubo bobabini abavelisi zifumane imvume yongxamiseko.

46
00:05:20,413 --> 00:05:26,674
Oku kubeka umngcipheko wezempilo
ongathandabuzekiyo nongayimfuneko kwaphela.

47
00:05:26,674 --> 00:05:38,531
Ukupakishwa kwe-RNA kwi-LNP kuyikhusela ekonakalisweni, kuyivumela
ukuba ifikelele kuzo zonke izitho zomzimba ngokuphuma egazini.

48
00:05:38,531 --> 00:05:44,520
Apho, ii-LNPs zisebenza njengeehashe zaseTroya.

49
00:05:44,520 --> 00:05:49,040
Zifunxwa zii-seli kwaye i-mRNA ikhutshwe.

50
00:05:49,040 --> 00:05:52,457
Oku kulandelwa ngukwenziwa kwe-spike protein.

51
00:05:52,457 --> 00:05:58,389
Oku ke kubangela impendulo yokhuselo lomzimba,
kuquka ukwenziwa kwee-antibodies ezithile

52
00:05:58,389 --> 00:06:03,180
ezenzelwe ukusikhusela kusulelo lwexesha elizayo.

53
00:06:03,180 --> 00:06:09,954
Nangona kunjalo, inkqubo yokhuselo lomzimba iyaziqonda kwaye
itshabalalise iiseli zomzimba ezivelisa iiprotheyini ezingezizo.

54
00:06:09,954 --> 00:06:15,467
Ngokwendalo, oku kwenzeka xa iiseli
zethu zosulelwa ziintsholongwane.

55
00:06:15,467 --> 00:06:22,171
Le nkono yokuqaphela iiproteni
zangaphandle njengoko zinjalo sele ikhona ekuzalweni.

56
00:06:22,171 --> 00:06:26,593
Isikhusela kubo bonke ubomi bethu, njengoko
iiseli ezosulelekileyo yintsholongwane

57
00:06:26,593 --> 00:06:29,736
zitshatyalaliswa ngokufanelekileyo ngale ndlela.

58
00:06:29,736 --> 00:06:31,900
Ayinakucinezelwa.

59
00:06:31,900 --> 00:06:41,803
Ngoko ke, xa i-mRNA equlethe iproteni engaphandle ifakwa
kwiseli, loo seli ihlaselwa yinkqubo yokhuselo lomzimba.

60
00:06:41,803 --> 00:06:48,040
Ukuphikiswa kwamalungu afakelweyo kubonisa le nyaniso isisiseko.

61
00:06:48,040 --> 00:06:52,145
Ukuba ufumana isintso sam, umzimba wakho awuzukusamkela.

62
00:06:52,145 --> 00:06:59,508
Ufumana isintso sam sesibini, kwaye ukwaliwa kwesibini kulandela,
kodwa ngeli xesha ngokukhawuleza nangomsindo ongaphezulu.

63
00:06:59,508 --> 00:07:09,685
Iimigaqo ezifanayo zisekela iziphumo eziyingozi ezisoloko
zanda zokuqhutywa kwezito ze-vaccine ngokuphindaphindiweyo.

64
00:07:09,685 --> 00:07:19,740
Inani leekopi ze-RNA ezipakishiweyo kwi-LNP
ezifakwa ngesitofu ngasinye likhulu kakhulu.

65
00:07:19,740 --> 00:07:25,562
Iiseli ezingenakubalwa emzimbeni wonke ziya
kuhlaselwa yinkqubo yethu yokhuselo lomzimba.

66
00:07:25,562 --> 00:07:34,718
Olu hlaselo lunokunqandwa kuphela xa
imveliso yeprotheyini engaphandle iye yema.

67
00:07:34,718 --> 00:07:37,632
Kodwa oku kuza kuhlala ixesha elingakanani?

68
00:07:37,632 --> 00:07:45,566
Kusele iintsuku nje ezimbalwa, njengoko abavelisi
begcisho kunye namagunya olawulo besisoloko besiqinisekisa?

69
00:07:45,566 --> 00:07:54,781
Kule minyaka mibini idlulileyo, kuye kwenziwa
iingqwalasela ezothusayo ezingahambelaniyo nesi sibheno.

70
00:07:54,781 --> 00:08:05,047
Kubantu abagonyiweyo, iproteni ye-spike kunye nokudumba zifunyenwe
kumalungu amaninzi emizimba kwiiveki nakweenyanga emva kokugonywa

71
00:08:05,047 --> 00:08:10,649
, nto leyo ebinxulumene nezifo ezinzima nezisoloko zibulala.

72
00:08:10,649 --> 00:08:19,700
Kodwa le mveliso ingalindelekanga, eqhubekayo
yeprotheyini efunyenwe kwi-mRNA ingacaciswa njani?

73
00:08:19,700 --> 00:08:36,372
Impendulo ekholisayo kodwa eyothusayo yanikezelwa lufumaniso
lukaMcKernan noogxa bakhe, abalupapashe kunyaka ophelileyo.

74
00:08:36,372 --> 00:08:45,762
Sasisele sixoxile ukuba i-mRNA yenziwa kusetyenziswa
iitemplethi zeplasmid DNA ngexesha lemveliso yesitofu sokugonya.

75
00:08:45,762 --> 00:08:54,214
Phambi kokuba i-mRNA ipakishwe
kwi-LNP, le DNA kufuneka ikuqala isuswe.

76
00:08:54,214 --> 00:09:03,558
Kungenjalo, i-DNA yeplasmid
ingavalelwa kwiigolubhu ze-lipid kunye ne-RNA.

77
00:09:03,558 --> 00:09:14,880
UMcKernan wafumanisa ukuba eli nyathelo libalulekileyo
lokususa i-plasmid DNA belingazange lisenziwe ngononophelo.

78
00:09:14,880 --> 00:09:24,894
Kufunyenwe i-plasmid DNA egqithisileyo
kwiibhetshi ezininzi zezitofu zokugonya zePfizer neModerna.

79
00:09:27,086 --> 00:09:34,145
Izifunyaniso zikaKevin McKernan zathotywa
amehlo ngabantu abaninzi abaqhelekileyo.

80
00:09:34,145 --> 00:09:46,430
Abaphathi abalawulayo bathe abavelisi babazisile ngobukho be-DNA;
nangona kunjalo, oku akuzange kubathintele ekunikezeni imvume,

81
00:09:46,430 --> 00:09:52,920
njengoko amanani axeliweyo ayephantsi kwemida ebekwe yi-WHO.

82
00:09:52,920 --> 00:09:55,941
Kodwa la mda avela phi?

83
00:09:55,941 --> 00:10:06,135
I-Arhente yaseYurophu yeeMithi (EMA) ibimise umda
wama-10 eenanogram ze-DNA kwidosi nganye yesitofu sokugonya.

84
00:10:06,135 --> 00:10:13,127
Ubalise ingxelo ye-WHO yango-1998.

85
00:10:13,127 --> 00:10:22,527
Le ngxelo yobuchwepheshe ithi: "Ngokusekelwe kulwazi lwangoku,
i-DNA evela kwiilayini zeeseli eziqhubekayo ukuya kutsho kwi-10ng

86
00:10:22,527 --> 00:10:27,936
kwidosi nganye ecociweyo ngoku inokuthathwa njengeyamkelekileyo."

87
00:10:27,936 --> 00:10:35,174
Umda omtsha ophezulu awusebenzi kwiimveliso
ezifunyenwe kwiseli zeentsholongwane, iintambo

88
00:10:35,174 --> 00:10:42,061
zeseli ze-diploid okanye iinkcubeko zeseli zokuqala.

89
00:10:42,061 --> 00:10:47,704
Sibona ukuba ingxelo ye-WHO yahlula
phakathi kweentlobo ezimbini ze-DNA.

90
00:10:47,704 --> 00:10:55,760
Enye ithathwa njengoyingozi ngaphezu kwenye, kwaye
ngenxa yoko isixa sayo sinqunyelwe kwixabiso elimisiweyo.

91
00:10:55,760 --> 00:11:02,481
Kodwa i-DNA yeplasmid efumaneka kwiigonyo ze-mRNA
ingena koluphi lwezi ndidi zimbini – kolona

92
00:11:02,481 --> 00:11:08,079
lunobungozi ngakumbi okanye kolona lunobungozi obuncinci?

93
00:11:08,079 --> 00:11:17,688
Ayikho kwelinye lala maqela, kuba umgaqo-nkqubo we-WHO
ngokungaqondakalanga uthatha ngokuba nayiphi na i-DNA efumaneka

94
00:11:17,688 --> 00:11:25,154
kumayeza okanye kwisitofu sokugonya ayinto
ingaphaya koko: yi-DNA 'engagqunywanga', ukufunxwa kwayo

95
00:11:25,154 --> 00:11:29,880
kwiiseli zomzimba wethu kuya kuba buthathaka kakhulu.

96
00:11:29,880 --> 00:11:42,794
Ngokwahlukileyo, nangona kunjalo, i-DNA engcolisayo
okwi-vaccine iya kuba isongelwe nge-LNP, kanye njenge-mRNA.

97
00:11:42,794 --> 00:11:49,960
Le ndlela yokupakisha ibangela ukufunxwa kwe-DNA
okusebenza ngcono kakhulu kwiseli zomzimba wethu .

98
00:11:49,960 --> 00:11:57,820
Kungoko bekuya kuba yimfuneko ukumisela umda
"okhuselekileyo" we-DNA ephakwe kwi-LNP kusetyenziswa

99
00:11:57,820 --> 00:12:01,510
iimvavanyo ezintsha, ezicwangciswe ngononophelo.

100
00:12:01,510 --> 00:12:07,479
Kodwa masithi umda obekwe yi-EMA uyamkeleka.

101
00:12:07,479 --> 00:12:10,860
Oku kusisa phi?

102
00:12:10,860 --> 00:12:19,777
Kwingxelo yayo ekhankanyiweyo , i-EMA ithi zonke iisampulu
zesitofu sokugonya ezazifumene kwi-Pfizer/BioNTech phambi

103
00:12:19,777 --> 00:12:25,175
kokuba kugunyaziswe zazihambelana nomda we-EMA we-DNA eseleyo.

104
00:12:25,175 --> 00:12:31,709
Nangona kunjalo, kucacile ukuba i-EMA ayiqinisekisanga ulawulo
lomgangatho oluqhubekayo emva kokuvunywa,

105
00:12:31,709 --> 00:12:37,995
kwaye okufanayo kusebenza kuzo zonke
ezinye iigunya zolawulo kwihlabathi jikelele.

106
00:12:37,995 --> 00:12:46,564
Oku kungafunyaniswa kwiziphumo zikaKevin McKernan,
ngokutsho kwazo umthamo we-DNA kuzo zonke iibhetshi

107
00:12:46,564 --> 00:12:53,021
zesitofu esivavanyiweyo ugqitha umda obekwe yi-WHO ne-EMA.

108
00:12:54,556 --> 00:13:04,889
Oku kusikhokelela kwisithethweni esothusayo nesimangalisayo
sokuba ezi zitofu zokugonya zintlekele zenziwe ngaphandle kwayo

109
00:13:04,889 --> 00:13:16,388
nayiphi na ulawulo, nokuba amakhulu ezigidi abantu bafakwe iidosi
zezitofu ezaphula ngokugqithisileyo imiqathango yokuvunywa.

110
00:13:16,388 --> 00:13:25,878
Ngoku akuvumelekanga ukutofwa kwamayeza
angahambelaniyo nemiqathango ebekwe kwimvume yokuthengisa.

111
00:13:25,878 --> 00:13:33,085
Ngoko ke, ukuqhubeka nokufakwa kwezi zitofu zokugonya
akukho nto yahlukileyo kunenyathelo lolwaphulo-mthetho.

112
00:13:33,085 --> 00:13:42,314
Kubonakala ukuba oolawulo lwethu baphantsi
kangakanani kwezazi, kangangokuba benza oku

113
00:13:42,314 --> 00:13:47,488
kubemi babo kwaye beqhubeka nokwenza njalo.

114
00:13:47,488 --> 00:13:54,805
Qaphela: Abasemagunyeni abafanelekileyo kumazwe
aseNtshona baye balile ngokukhutheleyo ukuphanda

115
00:13:54,805 --> 00:13:59,444
ukuba iqela likaMcKernan lisenokuba linyaniso na.

116
00:13:59,444 --> 00:14:06,715
Endaweni yoko, bakhwaza ngamxhelo
mnye: I-DNA ayizukufikelela nakwiiseli.

117
00:14:06,715 --> 00:14:14,166
Kwaye ukuba kuyenzeka, iya kudodobala
ngokukhawuleza ize itshatyalaliswe apho.

118
00:14:14,166 --> 00:14:24,295
Ngaphezu koko, inyukliya yeseli yahlulwe kwi-cytosol yeseli
ngemembrane engenakungena kuyo, ngoko ke i-DNA engengeyayo

119
00:14:24,295 --> 00:14:31,336
ayinakuze ingene kwinyukliya ukuze yenze umsebenzi wayo apho.

120
00:14:31,336 --> 00:14:41,420
Ekuphela kwento elungileyo ngeli bali loyikisayo
kukuba abasemagunyeni abaxanduva ngoku bazityhile.

121
00:14:41,420 --> 00:14:47,567
Baphakathi kwengxaki enkulu, kwaye oku kucacele wonke umntu.

122
00:14:47,567 --> 00:14:56,818
Kucacile ukuba amaziko karhulumente
asebenzisana nabenzi bolu lwaphulo-mthetho luyinkohlakalo.

123
00:14:56,818 --> 00:15:06,260
Okufunyenwe nguMcKernan kufanele kukhuthaze inkxalabo
kuye nabani na onolwazi oluncinci nje lwebhayoloji.

124
00:15:06,260 --> 00:15:14,740
Kucacile ukuba i-DNA yeplasmid ephakwe kwi-LNP iya
kungena kwiiseli zethu ngokunempumelelo okuphezulu.

125
00:15:14,740 --> 00:15:22,168
Imembrane yenyukliya ayikwazi ukukhusela iikhromosom
ngokuqhubekayo; iyanyibilika ngexesha lokwahlukana

126
00:15:22,168 --> 00:15:30,600
kweseli nganye, kwaye i-DNA engaphandle ke ifakwa
kwiinyukliya ezisandul' ukwenziwa zeeseli ezingentombi.

127
00:15:30,600 --> 00:15:39,814
Oku kungeniswa kuphela kwanele ukukhuthaza imveliso
yexesha elide yeeprotheyini ezifakwe ikhowudi –

128
00:15:39,814 --> 00:15:46,528
ukudityaniswa kwi-DNA yee-chromosomes zethu akuyomfuneko koku .

129
00:15:46,528 --> 00:15:54,920
Kwelinye icala, ukuba olu dityaniso
luyenzeka, lubeka iingozi ezongezelelweyo.

130
00:15:54,920 --> 00:16:02,620
Iziphumo zikaMcKernan ukusukela ngoko ziye
zaqinisekiswa zezinye iilabhoratri eUnited States naseCanada.

131
00:16:02,620 --> 00:16:09,290
Ngoku sinika ingxelo ngemilinganiselo
eyongezelelweyo eyenziwe liqela labaphandi baseJamani

132
00:16:09,290 --> 00:16:14,675
abanamava kwiibhetshi zesitofu sokugonya i-BioNTech.

133
00:16:16,863 --> 00:16:27,250
Isiphumo sokuqala: Njengakuqala, i-DNA eninzi yeebhaktheriya
ifunyenwe kuzo zonke iibhetshi ezintandathu eziye zavavanywa.

134
00:16:27,250 --> 00:16:35,700
Zonke izinto zofuzo ezazifunyenwe ngaphambili
nguMcKernan kwi-plasmid zichongwe nakulapha.

135
00:16:35,700 --> 00:16:44,707
Oku kukwabandakanya le nto kuthiwa yi-SV40 promoter,
icandelo elikhetheke kakhulu ubukho balo obubegcinwe

136
00:16:44,707 --> 00:16:50,098
buyimfihlo eluntwini nakwabasemagunyeni abalawulayo.

137
00:16:50,098 --> 00:16:59,662
Isizathu sokuba iPfizer neBioNTech zifake ipromoter
ye-SV40 kwi-plasmid yazo sisombuzo onomdla kakhulu.

138
00:16:59,662 --> 00:17:07,225
Le nxalenye ayifuneki kwimveliso ye-spike
mRNA, kwaye ayikabikho kwiplazmidi

139
00:17:07,225 --> 00:17:13,297
esetyenziswa yiModerna kwimveliso yesitofu sokugonya.

140
00:17:13,297 --> 00:17:21,381
Nangona kunjalo, ipromota ye-SV40 inamandla anomtsalane
okuzingcatshela yona kunye neenkqubo ze-DNA

141
00:17:21,381 --> 00:17:31,320
ezincanyathiselwe kuyo ngaphakathi kwelaphu lenyukliya
elingagqagqwanga, kwanakwizicwili ezingahluliyo ngoku.

142
00:17:31,320 --> 00:17:38,031
Siyakushiya kuwe ukuba ucinge ukuba oko kuthetha ntoni.

143
00:17:38,031 --> 00:17:46,533
Umbuzo olandelayo ngulo: Ingaba i-plasmid DNA
ingangeniswa kwiiseli zomntu ize ihlale apho ixesha elide?

144
00:17:46,533 --> 00:17:49,502
Impendulo yiyo!

145
00:17:49,502 --> 00:17:59,073
Iqela lophando lifumanise ukuba ukufunxwa kwe-DNA kwenzeka
ngokukhawuleza kwaye ihlala kwiiseli iintsuku ezininzi emva

146
00:17:59,073 --> 00:18:05,024
koko, isabonakala nokuba kudlule umjikelo wokwahlukana kweeseli.

147
00:18:05,024 --> 00:18:12,811
Ingxelo yokuba i-DNA etyiweyo itshatyalaliswa
ngokukhawuleza ke ngoko bubuxoki obupheleleyo

148
00:18:12,811 --> 00:18:18,138
– yinkcazelo engeyonyani eyingozi kwezempilo.

149
00:18:20,636 --> 00:18:32,386
Ngoku zininzi imizekelo yokufakwa kweDNA yangaphandle kwincwadi
yobomi, nakwii-chromosomes zeeseli nezilwanyana zaselebhu.

150
00:18:32,386 --> 00:18:36,600
Iziphumo ezinokubakho zininzi kwaye azinakubonwa kwangaphambili.

151
00:18:36,600 --> 00:18:46,293
Ukuphazamiseka kwindlela ecwangciswe kakuhle elawula
ukwahlukana nophuhliso lweeseli kunokukhokelela kumhlaza.

152
00:18:46,293 --> 00:18:53,650
Utshintsho kwimijini esebenza njengenxalenye yenkqubo
yokhuselo lomzimba lunokukhokelela ekusebenzeni kwayo kakubi.

153
00:18:53,650 --> 00:19:03,420
Ukuphazamiseka kwejini kwiseli yengqondo
kunokubangela nasiphi na isifo sengqondo esinokucingelwa.

154
00:19:03,420 --> 00:19:11,879
Ukuba i-DNA yangaphandle ingena kwiikhromosom
zembewu yendoda okanye kumaqanda akhulisweyo,

155
00:19:11,879 --> 00:19:18,340
iimpawu ezitshintshileyo ezivayo ziya kudluliseleka.

156
00:19:18,340 --> 00:19:21,798
Oku kusizisa kumbuzo wethu wokugqibela:

157
00:19:24,732 --> 00:19:35,400
Ngaba kufanele sikhathazeke ukuba i-DNA yebhaktiriya
evela kwi-vaccine inokufakwa nakwiikhromosom zomntu?

158
00:19:35,400 --> 00:19:45,196
Ukuze kucaciswe lo mbuzo, iqela laseJamani lathumela iisampulu
zazo zeeseli ezinyangiweyo ngesitofu sokugonya kuKevin,

159
00:19:45,196 --> 00:19:50,849
licela ukulandelelaniswa okupheleleyo kwe-DNA yezo seli.

160
00:19:50,849 --> 00:19:56,254
Iziphumo zinokubonwa kwi-Substack kaKevin .

161
00:19:56,254 --> 00:20:00,620
Impendulo kwakhona yile: ewe!

162
00:20:00,620 --> 00:20:11,267
Ukufunyanwa kwe-DNA yebhaktheriya kwii-chromosomes
zeeseli ezinjalo okwangoku kuphantse kwagqitywa.

163
00:20:11,267 --> 00:20:23,426
Ukuba oku kwenzeka kwiiseli ezikwanti, ingaba ikhona na isizathu
esibonakalayo sokuba kungafanelanga kwenzeke nakumzimba?

164
00:20:23,426 --> 00:20:29,112
Ngeli xesha, kwaye kuphela ngeli
xesha, impendulo yethu yithi hayi.

165
00:20:29,112 --> 00:20:39,108
Namhlanje, apha nangoku, sijamelene nokuqonda ukuba oorhulumente
kwihlabathi jikelele baqalise inkqubo yobudayimane

166
00:20:39,108 --> 00:20:49,760
eyenzakalisile, yabulala kwaye yatshintsha imfuza
yezigidi zabantu abangathamsanqanga kwihlabathi jikelele.

167
00:20:49,760 --> 00:20:59,839
Kwaye le nkqubo iza kwandiswa; i-WHO ijolise ekutshintsheni
izitofu zokugonya eziqhelekileyo kumayeza abantu nawokunyanga

168
00:20:59,839 --> 00:21:06,227
izilwanyana ngamalungiselelo ezitofu ze-mRNA kuyo yonke indawo.

169
00:21:06,227 --> 00:21:13,455
I-WHO isixelela ukuba izitofu zokugonya i-COVID zibonakalise
ukhuseleko lwazo ngendlela echukumisayo kangangokuba

170
00:21:13,455 --> 00:21:21,568
uvavanyo olucokisekileyo lwezitofu ze-mRNA ezizayo
ngokuchasene nezinye izinto ezibangela izifo alusafuneki.

171
00:21:21,568 --> 00:21:31,812
Kodwa akukho nto ikude nenenyani njengesi
sibhengezo sisothukileyo sokutshona kwezifundo zonyango.

172
00:21:31,812 --> 00:21:41,020
Zihlobo ezithandekayo, ngenxa yenu nangenxa
yabo nibathandayo, ningaze niyilibale le nto inye:

173
00:21:41,020 --> 00:21:46,786
Ukuvela kwe-antigen engeloyi kwiseli
yomzimba wethu kuya kuhlala kukhokelela

174
00:21:46,786 --> 00:21:51,795
ekuhlaselweni kwaloo seli lulwakhiwo lokhuselo lomzimba.

175
00:21:51,795 --> 00:22:00,354
Ngenxa yokuba isitofu sogcino-zifo esitsha ngasinye se-mRNA
sinomzimba wasemzini waso, ngasinye kuzo nako kuza

176
00:22:00,354 --> 00:22:10,000
kubangela umonakalo, kanye njengoko sibonileyo
kwizitofu ezilungiswe ngokwezofuzo ezichasene ne-COVID-19.

177
00:22:10,000 --> 00:22:17,609
Kwaye njengakuqala, monakalo lo uya
kuba mbi ngakumbi ngalo lonke uhlaziyo.

178
00:22:17,609 --> 00:22:27,175
Ukukrwella kwezitofu ze-mRNA kunokwenzeka ukuba kuya kuba yinto
eqhelekileyo, kuba akukho ndlela inexabiso elifanelekileyo

179
00:22:27,175 --> 00:22:36,741
yokwahlula ngokuthembekileyo i-mRNA eveliswe ngobuninzi
kwii-plasmids – kwaye nangayiphi na imeko, akukho mntu ubonakalayo

180
00:22:36,741 --> 00:22:43,051
ojonga ukuthotyelwa kwayo nayiphi na imigangatho yokuvelisa.

181
00:22:43,051 --> 00:22:45,860
Inkqubo ye-WHO sisoyikiso kuluntu.

182
00:22:45,860 --> 00:22:49,346
Iwusongela WENA nabo ubathandayo.

183
00:22:49,346 --> 00:22:56,453
Bantu behlabathi, manyanani nisisindise kule ntsila yobugebenga!

184
00:22:56,453 --> 00:23:03,890
Masiyeke izitofu ze-mRNA – masiyeke i-WHO!

185
00:23:13,921 --> 00:23:19,759
Molo, igama lam ndinguLara kwaye
namhlanje ndiza kunixelela ibali lam.

186
00:23:19,759 --> 00:23:21,290
Igama lam ndinguLara.

187
00:23:21,290 --> 00:23:24,848
Igama lam ndinguLara, kwaye ndibe neminyaka
engamashumi amabini kwinyanga ephelileyo.

188
00:23:24,848 --> 00:23:30,215
Igama lam ndinguLara, ndineminyaka engamashumi amabini ubudala,
kwaye kwiiveki ezimbini phambi komhla wam wokuzalwa weshumi

189
00:23:30,215 --> 00:23:34,063
elinesibhozo, ndalahlekelwa ngesiquphe ngamandla okuhamba.

190
00:23:34,063 --> 00:23:42,943
Kwiintsuku ezintathu emva kokufumana isitofu sam sesithathu
se-coronavirus ngomhla we-17 kaJanuwari 2022, ndaye ndatyhafa.

191
00:23:42,943 --> 00:23:52,431
Xa ndaphaphama, ndandibhideke ngokupheleleyo kwaye imilenze
yam yayingasakwazi ukundixhasa. Ndingasakwazi nje ukuhamba.

192
00:23:52,431 --> 00:23:55,931
Andisokuze ndiyilibale le mhla kungekudala.

193
00:23:55,931 --> 00:24:03,188
Emva kweyure, nam ndiye ndaqala ukufumana ubunzima
bokuphefumla, ndaza ndasiwa kwisibhedlele sabantwana.

194
00:24:03,188 --> 00:24:05,063
Ewe.

195
00:24:07,345 --> 00:24:12,260
Kwixesha elalandelayo, imeko yam ayizange itshintshe kakhulu.

196
00:24:12,260 --> 00:24:15,758
Nezandla zam bezingakwazi ukubamba izinto kakuhle.

197
00:24:15,758 --> 00:24:18,243
Ndichithe iintsuku zam ndilele ebhedini.

198
00:24:18,243 --> 00:24:25,149
Ukufunda kwakungenakwenzeka kuba ngesigama sesithathu
kwisivakalisi, ndandisele ndilibele amagama amabini okuqala...

199
00:24:25,149 --> 00:24:26,657


200
00:24:26,657 --> 00:24:30,092
Umculo neevidiyo bezindigcina ndingodwa.

201
00:24:30,092 --> 00:24:35,217
Kwongezwa ukungakwazi ukuzibamba, igama ebendingalazi nokulazi.

202
00:24:35,217 --> 00:24:39,060
Ndandivalelwe ebhedini iinyanga ezine.

203
00:24:39,060 --> 00:24:41,451
Ndandisandul' ukuba neminyaka elishumi elinesibhozo.

204
00:24:41,451 --> 00:24:48,120
Kum, elo beliya kuba lixesha lokuphuma,
ndidibane nabahlobo, ndonwabele inkululeko yam.

205
00:24:48,120 --> 00:24:51,273
Kodwa bendibotshelelwe ebhedini.

206
00:24:51,273 --> 00:24:54,648
Abahlobo bavalelise omnye emva komnye.

207
00:24:54,648 --> 00:25:02,408
Kwelinye icala, kundivisa ubuhlungu kakhulu, kodwa
kwelinye icala, wenzeni ngomntu ohlala nje ethe saa ekhaya?

208
00:25:02,408 --> 00:25:06,135
Andikwazi ukuzicacisela yonke le nzame ilandelileyo.

209
00:25:06,135 --> 00:25:08,593
Kungagqitha eli xesha.

210
00:25:08,593 --> 00:25:12,197
Ndiza kuyichaza ngamagama angundoqo.

211
00:25:12,197 --> 00:25:15,619
I-acupuncture indibuyisele ezinyaweni.

212
00:25:15,619 --> 00:25:17,860
Ndiphinda unyaka esikolweni.

213
00:25:17,860 --> 00:25:23,150
Ndiya kuhamba iihambo ezimbini
ezimfutshane, eParis naseRoma. Halala!

214
00:25:23,150 --> 00:25:29,096
Kodwa ngoSeptemba 2022... Kudimala ubunzima obunzulu.

215
00:25:29,096 --> 00:25:31,330
Ukuqalisa kwakhona kuyaqala.

216
00:25:31,330 --> 00:25:33,486
Andisakwazi ukuya kwakhona.

217
00:25:33,486 --> 00:25:37,273
Ndizama ukuphinda iklasi. Ayisebenzi.

218
00:25:37,273 --> 00:25:39,391
Ukutsho iintlobo zezikolo, kulungile.

219
00:25:39,391 --> 00:25:40,953
Akusekho ikholeji yefom yesithandathu.

220
00:25:40,953 --> 00:25:42,740
Kodwa utshintsho lulungile.

221
00:25:42,740 --> 00:25:48,462
Ndiza kufumana izikwekwetshu ukuze
ndikwazi ukuya esikolweni nakwiintsuku ezimbi.

222
00:25:48,462 --> 00:25:54,174
Kuqala ixesha lokuphindaphinda
koko kubizwa ngokuba kukuphinda uwe.

223
00:25:54,174 --> 00:25:58,720
Iinkqubo azisandi nceda kuba sendidiniwe kakhulu ngazo.

224
00:25:58,720 --> 00:26:04,727
Kufuneka ndamkele into
endingazange ndiyifune: isitulo esinamavili.

225
00:26:04,727 --> 00:26:06,965
Kodwa ndiyakwazi ukuya esikolweni.

226
00:26:06,965 --> 00:26:10,987
Emva koko ndaphila ngendlela yokuphinda ndiwele.

227
00:26:10,987 --> 00:26:14,404
Ngoku sendifunde ukuphila nokuphinda ndiwele.

228
00:26:14,404 --> 00:26:20,075
Ukusukela ngaloo mini kaJanuwari 2022, ubomi
bam bebunje njengohambo oluzantsi naphakathi:

229
00:26:20,075 --> 00:26:26,948
Ukuphinda, ikhefu, ukuphinda
okungaphelelanga, ikhefu, ukuphinda okukhulu, ikhefu.

230
00:26:26,948 --> 00:26:31,335
Akululanga. Kodwa ndiyakwazi ukukwenza. Ndifuna ukukwenza.

231
00:26:31,335 --> 00:26:33,862
Ndinephupha ezininzi.

232
00:26:33,862 --> 00:26:40,086
Kule minyaka mibini idlulileyo, bendixakeke
kakhulu yinto enokubonakala ingabalulekanga.

233
00:26:40,086 --> 00:26:42,134
Bendingazi ukuba ndinantoni.

234
00:26:42,134 --> 00:26:43,959
Akukho mntu wayesazi.

235
00:26:43,959 --> 00:26:50,168
Ndiyayikhumbula loo mini umama wam afumanisa ngayo
kwi-intanethi ukuba isifo sam esingenagama sasinayo

236
00:26:50,168 --> 00:26:53,880
nayo igama: i-Post-Vac Syndrome, i-Post-Vac Syndrome.

237
00:26:53,880 --> 00:26:58,335
Ngoku ndingahleka ngayo. Kuba ayilotyathanga ngokwenene.

238
00:26:58,335 --> 00:27:00,020
Kodwa ndandiyonwabile.

239
00:27:00,020 --> 00:27:02,638
Ngoku ndiyazi ukuba kutheni ibibaluleke kangaka kum.

240
00:27:02,638 --> 00:27:08,300
Kuba umntu othile wayendibonile
ngequbuliso. Kwaye imeko yam yayinesigama.

241
00:27:08,300 --> 00:27:11,537
Kuba ndabelane nabanye ngesigulo sam.

242
00:27:11,537 --> 00:27:13,312
Bendingasadidwa.

243
00:27:13,312 --> 00:27:15,946
Kwaye kwandikhulula.

244
00:27:15,946 --> 00:27:23,257
Emva kweemvavanyo ezininzi, ezazisoloko ziphela ngokuba
"yonke into iqhelekile," ekugqibeleni ndifunyaniswe ndinezi zifo

245
00:27:23,257 --> 00:27:27,934
zimbini: i-small fibre neuropathy kunye ne-fatigue syndrome.

246
00:27:27,934 --> 00:27:34,200
Kolu hambo lude, andifumananga kuphela
amava amabi ngononophelo lwezempilo.

247
00:27:34,200 --> 00:27:36,580
Oogqirha abambalwa babesenza izigqibo.

248
00:27:36,580 --> 00:27:41,752
Undincedile ukuba ndiqhubele phambili kancinci,
kwaye ndiyakubulela ukusuka ezantsi zentliziyo yam.

249
00:27:41,752 --> 00:27:43,873
Ndisemgibeni onyukayo we-roller coaster.

250
00:27:43,873 --> 00:27:45,780
Akukapheli.

251
00:27:45,780 --> 00:27:47,700
Kodwa ngoku sele ithe tyaba.

252
00:27:47,700 --> 00:27:49,003
Ndiyathemba ukuba kuya kuhlala kunjalo.

253
00:27:49,003 --> 00:27:53,264
Kwaye ndinethemba lokuba ngenye imini ndiza
kukwazi ukuphuma kule rollercoaster ngokupheleleyo.

254
00:27:53,264 --> 00:27:58,699
Kungakuhle ukuma emhlabeni ngemilenze yam esebenzayo.

255
00:27:58,699 --> 00:28:00,730
Qhubeka nokuphanda!

256
00:28:00,730 --> 00:28:08,476
Sonke sidinga umbono. Kwaye ndikudinga wena. Enkosi.

257
00:28:11,867 --> 00:28:18,268
Umbutho we-MWGFD wenze udliwano-ndlebe olongezelelweyo
oluchukumisayo nolubambekayo nabantu abonzakaliswe ziigonyo

258
00:28:18,268 --> 00:28:22,273
ze-mRNA kuthotho oluthi "bagonyiwe, bonzakaliswe, baphikiswe".

259
00:28:22,273 --> 00:28:25,740
Ungazifumana ezi phantsi kwekhonkco elibonisweyo.

260
00:28:25,740 --> 00:28:32,449
Ngenxa yokuba itekhnoloji ye-mRNA iza kusetyenziswa nakwezinye
iinjongo zokugonya – okanye, ukuthetha ngokuchanekileyo,

261
00:28:32,449 --> 00:28:39,118
kunyango lwemfuza – kubaluleke ngakumbi ukwazisa
uluntu ngezi ngxelo zothuso ngomonakalo owenziwa yivayisi.

262
00:28:39,118 --> 00:28:42,797
Nceda uzive ukhululekile ukwabelana ngezi dili.

263
00:28:42,797 --> 00:28:50,346
Ungancedisa kwakhona ekukhanyiseni ubungakanani
bomonakalo obubangelwa ziigonyo ze-mRNA ngokuxela nawuphi na

264
00:28:50,346 --> 00:28:54,120
umonakalo wogonyo kwingingqi yakho kwi-vetopedia.org.