WEBVTT

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"Kwiintsuku ezintathu emva kokufumana isitofu sam sesithathu
se-COVID-19 ngomhla we-17 kaJanuwari 2022, ndaye ndatyhafa, kwaye

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xa ndaphaphama, ndandibhideke ngokupheleleyo kwaye imilenze
yam yayingasakwazi ukundixhasa. Ndingasakwazi nje ukuhamba."

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"Kubantu abagonyiweyo, iproteni ye-spike kunye nokudumba
zifunyenwe kumalungu amaninzi emizimba

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kwiiveki nakweenyanga emva kokugonywa, nto leyo
ebinxulumene nezifo ezinzima nezisoloko zibulala."

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Kodwa le mveliso ingalindelekanga neqhubekayo
yeprotheyini efunyenwe kwi-mRNA ingacaciswa njani?

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Ekupheleni kuka-2023, i-Kla.TV ipapashe ileta
engxamisekileyo kaNjingalwazi Gqr. Sucharit Bhakdi

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"ngeengozi ezingapheliyo zezitofu ze-RNA" ngeelwimi ezininzi.

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Ngoku, ekupheleni kukaMatshi 2024, uNjing. Gqr. Sucharit Bhakdi,
uNjing. Karina Reiss kunye noGqr. Michael

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Palmer bapapashe inqaku apho iziphumo ezitsha
ziqinisekisa zonke izilumkiso ezenziwa ngelo xesha.

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Bachaza ngendlela yenzululwazi echanekileyo, kodwa ngendlela
eqondakala lula ngabantu abaqhelekileyo,

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ukuba kutheni izitofu zokugonya ezibizwa ngokuba
yi-mRNA zibubuxoki kwaye ziyingozi kakhulu.

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Eli nqaku liphandwe kakuhle lilungele ukwabelwana
ngalo nabani na ongakhange ayiphande le ngongoma nzulu.

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Inokufunyanwa njengefayile ye-PDF
phantsi kwale nkqubo ukuze iprintwe.

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Ngezantsi, uNjing. Bhakdi uyakufundela eli nqaku phezulu.

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Impembelelo ebonakalayo yeemeko ezichazwe nguNjingalwazi Bhakdi
kwabo sele benzakele iboniswa kwingxelo elandelayo kaLara.

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Ungomnye wamaxhoba amaninzi okugonywa nge-coronavirus kwaye
ubalisa ibali lakhe lobuhlungu kwi-symposium

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yabezindaba ye-MWGFD enesihloko esithi "Ugonyiwe,
wonzakaliswe, wakhanyelwa... kwaye ngoku yintoni?" Prof.

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Zihlobo ezithandekayo zoluntu. Sithandwa sisazisi somntu,
ndinento ebaluleke kakhulu, kakhulu endifuna ukunixelela yona.

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Imalunga nokufunyanwa kweDNA kutshanje kwizitofu zokugonya.

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Isizathu sokuba izitofu zokugonya ze-RNA zibubuxoki
kwaye ziyingozi kakhulu ngoku sisihloko esixoxwayo.

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Iikhromosom ziziincwadi zobomi, ezineeresiphi
ezikhowudwe kwi-DNA zokuveliswa kweemolekyuli zeprotheyini.

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Ukuba kuyimfuneko, kuvulwa incwadi
efanelekileyo kwaye kwenziwe ikopi yeresiphi efunwayo.

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Le kopi yi-mRNA.

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Ilawula imveliso yeprotheyini ize emva koko ilahlwe.

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Izijovo ze-RNA ziyafana nezi khopi zingahlali ixesha lide
zeeresiphi zeekhromosom; kodwa ngokungafaniyo nazo,

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zibangela ukuveliswa kweeprotheyini ezingekho kwimizimba yethu.

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Endaweni yoko, zibangela ukwenziwa kwee-antigens
ezingezizo, ezifana ne-spike protein ye-SARS-CoV-2.

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Ugonyo ngalunye lolu hlobo lunika iikopi
ezingaphezu kwebhiliyoni (iimolekyuli ze-mRNA).

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Ukuveliswa ngobuninzi kwesitofu se-mRNA
kufuna ukufumaneka ngobuninzi kweresiphi ye-DNA.

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Oku kunokufezekiswa njani?

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Indlela esetyenziselwe ukusombulula le ngxaki
isisiseko esibalulekileyo sobunjineli bemfuza.

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Iibhiliyoni neetiriliyoni zeekopi
zeeresiphi ze-DNA zivela kwiibhaktheriya.

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Iiresiphi zifumaneka kwiikhromosom ezincinci
zebhaktheriya ezibizwa ngokuba zii-plasmids.

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Iiseli zebhaktheriya zinokwahlukana qho emva
kwemizuzu engama-20, nto leyo ethetha ukuba inani

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leeseli liyanda ngokuphindwe kasibhozo ngeyure nganye.

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Ngale ndlela, iibhaktheriya ezingenakubalwa zinokuvunwa
kwinkcubeko elulwelo kwiintsuku nje

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ezimbalwa, kwaye iseli nganye yebhaktheriya iya kuba
neekopi ezininzi zeplasmid ekuthethwa ngayo.

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Iiplasmidi kulula ukuzilawula.

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Iirekhiphithi zangaphandle, oko kukuthi, iijini
ezikhowuda iiproteni zentsholongwane, umzekelo, zinokufakwa.

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Emva kokuzala kweebhaktheriya, iiplazmidi ziyavunwa zize
zisetyenziswe njengamatemplate ekwenzeni iikopi ze-mRNA.

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Ekugqibeleni, iimolekyuli ze-RNA zifakwa kwiigolibhu ezincinci
zamafutha ezibizwa ngokuba zii-lipid nanoparticles (LNPs).

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Iinxalenye eziphambili ze-LNP zenziwa
ngokwenziwa kwaye zaziwa ngokuba yityhefu ngokwazo.

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Ngaphezu koko, izidibanisi ezikhethekileyo ze-lipid
ezisetyenziswa yi-Pfizer/BioNTech ne-Moderna bezingekavavanywa

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nakubantu phambi kokuba izitofu zokugonya ze-mRNA
ezivela kubo bobabini abavelisi zifumane imvume yongxamiseko.

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Oku kubeka umngcipheko wezempilo
ongathandabuzekiyo nongayimfuneko kwaphela.

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Ukupakishwa kwe-RNA kwi-LNP kuyikhusela ekonakalisweni, kuyivumela
ukuba ifikelele kuzo zonke izitho zomzimba ngokuphuma egazini.

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Apho, ii-LNPs zisebenza njengeehashe zaseTroya.

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Zifunxwa zii-seli kwaye i-mRNA ikhutshwe.

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Oku kulandelwa ngukwenziwa kwe-spike protein.

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Oku ke kubangela impendulo yokhuselo lomzimba,
kuquka ukwenziwa kwee-antibodies ezithile

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ezenzelwe ukusikhusela kusulelo lwexesha elizayo.

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Nangona kunjalo, inkqubo yokhuselo lomzimba iyaziqonda kwaye
itshabalalise iiseli zomzimba ezivelisa iiprotheyini ezingezizo.

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Ngokwendalo, oku kwenzeka xa iiseli
zethu zosulelwa ziintsholongwane.

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Le nkono yokuqaphela iiproteni
zangaphandle njengoko zinjalo sele ikhona ekuzalweni.

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Isikhusela kubo bonke ubomi bethu, njengoko
iiseli ezosulelekileyo yintsholongwane

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zitshatyalaliswa ngokufanelekileyo ngale ndlela.

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Ayinakucinezelwa.

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Ngoko ke, xa i-mRNA equlethe iproteni engaphandle ifakwa
kwiseli, loo seli ihlaselwa yinkqubo yokhuselo lomzimba.

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Ukuphikiswa kwamalungu afakelweyo kubonisa le nyaniso isisiseko.

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Ukuba ufumana isintso sam, umzimba wakho awuzukusamkela.

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Ufumana isintso sam sesibini, kwaye ukwaliwa kwesibini kulandela,
kodwa ngeli xesha ngokukhawuleza nangomsindo ongaphezulu.

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Iimigaqo ezifanayo zisekela iziphumo eziyingozi ezisoloko
zanda zokuqhutywa kwezito ze-vaccine ngokuphindaphindiweyo.

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Inani leekopi ze-RNA ezipakishiweyo kwi-LNP
ezifakwa ngesitofu ngasinye likhulu kakhulu.

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Iiseli ezingenakubalwa emzimbeni wonke ziya
kuhlaselwa yinkqubo yethu yokhuselo lomzimba.

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Olu hlaselo lunokunqandwa kuphela xa
imveliso yeprotheyini engaphandle iye yema.

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Kodwa oku kuza kuhlala ixesha elingakanani?

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Kusele iintsuku nje ezimbalwa, njengoko abavelisi
begcisho kunye namagunya olawulo besisoloko besiqinisekisa?

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Kule minyaka mibini idlulileyo, kuye kwenziwa
iingqwalasela ezothusayo ezingahambelaniyo nesi sibheno.

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Kubantu abagonyiweyo, iproteni ye-spike kunye nokudumba zifunyenwe
kumalungu amaninzi emizimba kwiiveki nakweenyanga emva kokugonywa

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, nto leyo ebinxulumene nezifo ezinzima nezisoloko zibulala.

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Kodwa le mveliso ingalindelekanga, eqhubekayo
yeprotheyini efunyenwe kwi-mRNA ingacaciswa njani?

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Impendulo ekholisayo kodwa eyothusayo yanikezelwa lufumaniso
lukaMcKernan noogxa bakhe, abalupapashe kunyaka ophelileyo.

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Sasisele sixoxile ukuba i-mRNA yenziwa kusetyenziswa
iitemplethi zeplasmid DNA ngexesha lemveliso yesitofu sokugonya.

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Phambi kokuba i-mRNA ipakishwe
kwi-LNP, le DNA kufuneka ikuqala isuswe.

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Kungenjalo, i-DNA yeplasmid
ingavalelwa kwiigolubhu ze-lipid kunye ne-RNA.

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UMcKernan wafumanisa ukuba eli nyathelo libalulekileyo
lokususa i-plasmid DNA belingazange lisenziwe ngononophelo.

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Kufunyenwe i-plasmid DNA egqithisileyo
kwiibhetshi ezininzi zezitofu zokugonya zePfizer neModerna.

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Izifunyaniso zikaKevin McKernan zathotywa
amehlo ngabantu abaninzi abaqhelekileyo.

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Abaphathi abalawulayo bathe abavelisi babazisile ngobukho be-DNA;
nangona kunjalo, oku akuzange kubathintele ekunikezeni imvume,

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njengoko amanani axeliweyo ayephantsi kwemida ebekwe yi-WHO.

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Kodwa la mda avela phi?

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I-Arhente yaseYurophu yeeMithi (EMA) ibimise umda
wama-10 eenanogram ze-DNA kwidosi nganye yesitofu sokugonya.

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Ubalise ingxelo ye-WHO yango-1998.

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Le ngxelo yobuchwepheshe ithi: "Ngokusekelwe kulwazi lwangoku,
i-DNA evela kwiilayini zeeseli eziqhubekayo ukuya kutsho kwi-10ng

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kwidosi nganye ecociweyo ngoku inokuthathwa njengeyamkelekileyo."

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Umda omtsha ophezulu awusebenzi kwiimveliso
ezifunyenwe kwiseli zeentsholongwane, iintambo

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zeseli ze-diploid okanye iinkcubeko zeseli zokuqala.

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Sibona ukuba ingxelo ye-WHO yahlula
phakathi kweentlobo ezimbini ze-DNA.

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Enye ithathwa njengoyingozi ngaphezu kwenye, kwaye
ngenxa yoko isixa sayo sinqunyelwe kwixabiso elimisiweyo.

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Kodwa i-DNA yeplasmid efumaneka kwiigonyo ze-mRNA
ingena koluphi lwezi ndidi zimbini – kolona

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lunobungozi ngakumbi okanye kolona lunobungozi obuncinci?

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Ayikho kwelinye lala maqela, kuba umgaqo-nkqubo we-WHO
ngokungaqondakalanga uthatha ngokuba nayiphi na i-DNA efumaneka

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kumayeza okanye kwisitofu sokugonya ayinto
ingaphaya koko: yi-DNA 'engagqunywanga', ukufunxwa kwayo

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kwiiseli zomzimba wethu kuya kuba buthathaka kakhulu.

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Ngokwahlukileyo, nangona kunjalo, i-DNA engcolisayo
okwi-vaccine iya kuba isongelwe nge-LNP, kanye njenge-mRNA.

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Le ndlela yokupakisha ibangela ukufunxwa kwe-DNA
okusebenza ngcono kakhulu kwiseli zomzimba wethu .

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Kungoko bekuya kuba yimfuneko ukumisela umda
"okhuselekileyo" we-DNA ephakwe kwi-LNP kusetyenziswa

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iimvavanyo ezintsha, ezicwangciswe ngononophelo.

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Kodwa masithi umda obekwe yi-EMA uyamkeleka.

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Oku kusisa phi?

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Kwingxelo yayo ekhankanyiweyo , i-EMA ithi zonke iisampulu
zesitofu sokugonya ezazifumene kwi-Pfizer/BioNTech phambi

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kokuba kugunyaziswe zazihambelana nomda we-EMA we-DNA eseleyo.

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Nangona kunjalo, kucacile ukuba i-EMA ayiqinisekisanga ulawulo
lomgangatho oluqhubekayo emva kokuvunywa,

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kwaye okufanayo kusebenza kuzo zonke
ezinye iigunya zolawulo kwihlabathi jikelele.

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Oku kungafunyaniswa kwiziphumo zikaKevin McKernan,
ngokutsho kwazo umthamo we-DNA kuzo zonke iibhetshi

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zesitofu esivavanyiweyo ugqitha umda obekwe yi-WHO ne-EMA.

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Oku kusikhokelela kwisithethweni esothusayo nesimangalisayo
sokuba ezi zitofu zokugonya zintlekele zenziwe ngaphandle kwayo

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nayiphi na ulawulo, nokuba amakhulu ezigidi abantu bafakwe iidosi
zezitofu ezaphula ngokugqithisileyo imiqathango yokuvunywa.

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Ngoku akuvumelekanga ukutofwa kwamayeza
angahambelaniyo nemiqathango ebekwe kwimvume yokuthengisa.

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Ngoko ke, ukuqhubeka nokufakwa kwezi zitofu zokugonya
akukho nto yahlukileyo kunenyathelo lolwaphulo-mthetho.

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Kubonakala ukuba oolawulo lwethu baphantsi
kangakanani kwezazi, kangangokuba benza oku

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kubemi babo kwaye beqhubeka nokwenza njalo.

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Qaphela: Abasemagunyeni abafanelekileyo kumazwe
aseNtshona baye balile ngokukhutheleyo ukuphanda

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ukuba iqela likaMcKernan lisenokuba linyaniso na.

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Endaweni yoko, bakhwaza ngamxhelo
mnye: I-DNA ayizukufikelela nakwiiseli.

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Kwaye ukuba kuyenzeka, iya kudodobala
ngokukhawuleza ize itshatyalaliswe apho.

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Ngaphezu koko, inyukliya yeseli yahlulwe kwi-cytosol yeseli
ngemembrane engenakungena kuyo, ngoko ke i-DNA engengeyayo

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ayinakuze ingene kwinyukliya ukuze yenze umsebenzi wayo apho.

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Ekuphela kwento elungileyo ngeli bali loyikisayo
kukuba abasemagunyeni abaxanduva ngoku bazityhile.

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Baphakathi kwengxaki enkulu, kwaye oku kucacele wonke umntu.

14:47.567 --> 14:56.818
Kucacile ukuba amaziko karhulumente
asebenzisana nabenzi bolu lwaphulo-mthetho luyinkohlakalo.

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Okufunyenwe nguMcKernan kufanele kukhuthaze inkxalabo
kuye nabani na onolwazi oluncinci nje lwebhayoloji.

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Kucacile ukuba i-DNA yeplasmid ephakwe kwi-LNP iya
kungena kwiiseli zethu ngokunempumelelo okuphezulu.

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Imembrane yenyukliya ayikwazi ukukhusela iikhromosom
ngokuqhubekayo; iyanyibilika ngexesha lokwahlukana

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kweseli nganye, kwaye i-DNA engaphandle ke ifakwa
kwiinyukliya ezisandul' ukwenziwa zeeseli ezingentombi.

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Oku kungeniswa kuphela kwanele ukukhuthaza imveliso
yexesha elide yeeprotheyini ezifakwe ikhowudi –

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ukudityaniswa kwi-DNA yee-chromosomes zethu akuyomfuneko koku .

15:46.528 --> 15:54.920
Kwelinye icala, ukuba olu dityaniso
luyenzeka, lubeka iingozi ezongezelelweyo.

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Iziphumo zikaMcKernan ukusukela ngoko ziye
zaqinisekiswa zezinye iilabhoratri eUnited States naseCanada.

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Ngoku sinika ingxelo ngemilinganiselo
eyongezelelweyo eyenziwe liqela labaphandi baseJamani

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abanamava kwiibhetshi zesitofu sokugonya i-BioNTech.

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Isiphumo sokuqala: Njengakuqala, i-DNA eninzi yeebhaktheriya
ifunyenwe kuzo zonke iibhetshi ezintandathu eziye zavavanywa.

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Zonke izinto zofuzo ezazifunyenwe ngaphambili
nguMcKernan kwi-plasmid zichongwe nakulapha.

16:35.700 --> 16:44.707
Oku kukwabandakanya le nto kuthiwa yi-SV40 promoter,
icandelo elikhetheke kakhulu ubukho balo obubegcinwe

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buyimfihlo eluntwini nakwabasemagunyeni abalawulayo.

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Isizathu sokuba iPfizer neBioNTech zifake ipromoter
ye-SV40 kwi-plasmid yazo sisombuzo onomdla kakhulu.

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Le nxalenye ayifuneki kwimveliso ye-spike
mRNA, kwaye ayikabikho kwiplazmidi

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esetyenziswa yiModerna kwimveliso yesitofu sokugonya.

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Nangona kunjalo, ipromota ye-SV40 inamandla anomtsalane
okuzingcatshela yona kunye neenkqubo ze-DNA

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ezincanyathiselwe kuyo ngaphakathi kwelaphu lenyukliya
elingagqagqwanga, kwanakwizicwili ezingahluliyo ngoku.

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Siyakushiya kuwe ukuba ucinge ukuba oko kuthetha ntoni.

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Umbuzo olandelayo ngulo: Ingaba i-plasmid DNA
ingangeniswa kwiiseli zomntu ize ihlale apho ixesha elide?

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Impendulo yiyo!

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Iqela lophando lifumanise ukuba ukufunxwa kwe-DNA kwenzeka
ngokukhawuleza kwaye ihlala kwiiseli iintsuku ezininzi emva

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koko, isabonakala nokuba kudlule umjikelo wokwahlukana kweeseli.

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Ingxelo yokuba i-DNA etyiweyo itshatyalaliswa
ngokukhawuleza ke ngoko bubuxoki obupheleleyo

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– yinkcazelo engeyonyani eyingozi kwezempilo.

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Ngoku zininzi imizekelo yokufakwa kweDNA yangaphandle kwincwadi
yobomi, nakwii-chromosomes zeeseli nezilwanyana zaselebhu.

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Iziphumo ezinokubakho zininzi kwaye azinakubonwa kwangaphambili.

18:36.600 --> 18:46.293
Ukuphazamiseka kwindlela ecwangciswe kakuhle elawula
ukwahlukana nophuhliso lweeseli kunokukhokelela kumhlaza.

18:46.293 --> 18:53.650
Utshintsho kwimijini esebenza njengenxalenye yenkqubo
yokhuselo lomzimba lunokukhokelela ekusebenzeni kwayo kakubi.

18:53.650 --> 19:03.420
Ukuphazamiseka kwejini kwiseli yengqondo
kunokubangela nasiphi na isifo sengqondo esinokucingelwa.

19:03.420 --> 19:11.879
Ukuba i-DNA yangaphandle ingena kwiikhromosom
zembewu yendoda okanye kumaqanda akhulisweyo,

19:11.879 --> 19:18.340
iimpawu ezitshintshileyo ezivayo ziya kudluliseleka.

19:18.340 --> 19:21.798
Oku kusizisa kumbuzo wethu wokugqibela:

19:24.732 --> 19:35.400
Ngaba kufanele sikhathazeke ukuba i-DNA yebhaktiriya
evela kwi-vaccine inokufakwa nakwiikhromosom zomntu?

19:35.400 --> 19:45.196
Ukuze kucaciswe lo mbuzo, iqela laseJamani lathumela iisampulu
zazo zeeseli ezinyangiweyo ngesitofu sokugonya kuKevin,

19:45.196 --> 19:50.849
licela ukulandelelaniswa okupheleleyo kwe-DNA yezo seli.

19:50.849 --> 19:56.254
Iziphumo zinokubonwa kwi-Substack kaKevin .

19:56.254 --> 20:00.620
Impendulo kwakhona yile: ewe!

20:00.620 --> 20:11.267
Ukufunyanwa kwe-DNA yebhaktheriya kwii-chromosomes
zeeseli ezinjalo okwangoku kuphantse kwagqitywa.

20:11.267 --> 20:23.426
Ukuba oku kwenzeka kwiiseli ezikwanti, ingaba ikhona na isizathu
esibonakalayo sokuba kungafanelanga kwenzeke nakumzimba?

20:23.426 --> 20:29.112
Ngeli xesha, kwaye kuphela ngeli
xesha, impendulo yethu yithi hayi.

20:29.112 --> 20:39.108
Namhlanje, apha nangoku, sijamelene nokuqonda ukuba oorhulumente
kwihlabathi jikelele baqalise inkqubo yobudayimane

20:39.108 --> 20:49.760
eyenzakalisile, yabulala kwaye yatshintsha imfuza
yezigidi zabantu abangathamsanqanga kwihlabathi jikelele.

20:49.760 --> 20:59.839
Kwaye le nkqubo iza kwandiswa; i-WHO ijolise ekutshintsheni
izitofu zokugonya eziqhelekileyo kumayeza abantu nawokunyanga

20:59.839 --> 21:06.227
izilwanyana ngamalungiselelo ezitofu ze-mRNA kuyo yonke indawo.

21:06.227 --> 21:13.455
I-WHO isixelela ukuba izitofu zokugonya i-COVID zibonakalise
ukhuseleko lwazo ngendlela echukumisayo kangangokuba

21:13.455 --> 21:21.568
uvavanyo olucokisekileyo lwezitofu ze-mRNA ezizayo
ngokuchasene nezinye izinto ezibangela izifo alusafuneki.

21:21.568 --> 21:31.812
Kodwa akukho nto ikude nenenyani njengesi
sibhengezo sisothukileyo sokutshona kwezifundo zonyango.

21:31.812 --> 21:41.020
Zihlobo ezithandekayo, ngenxa yenu nangenxa
yabo nibathandayo, ningaze niyilibale le nto inye:

21:41.020 --> 21:46.786
Ukuvela kwe-antigen engeloyi kwiseli
yomzimba wethu kuya kuhlala kukhokelela

21:46.786 --> 21:51.795
ekuhlaselweni kwaloo seli lulwakhiwo lokhuselo lomzimba.

21:51.795 --> 22:00.354
Ngenxa yokuba isitofu sogcino-zifo esitsha ngasinye se-mRNA
sinomzimba wasemzini waso, ngasinye kuzo nako kuza

22:00.354 --> 22:10.000
kubangela umonakalo, kanye njengoko sibonileyo
kwizitofu ezilungiswe ngokwezofuzo ezichasene ne-COVID-19.

22:10.000 --> 22:17.609
Kwaye njengakuqala, monakalo lo uya
kuba mbi ngakumbi ngalo lonke uhlaziyo.

22:17.609 --> 22:27.175
Ukukrwella kwezitofu ze-mRNA kunokwenzeka ukuba kuya kuba yinto
eqhelekileyo, kuba akukho ndlela inexabiso elifanelekileyo

22:27.175 --> 22:36.741
yokwahlula ngokuthembekileyo i-mRNA eveliswe ngobuninzi
kwii-plasmids – kwaye nangayiphi na imeko, akukho mntu ubonakalayo

22:36.741 --> 22:43.051
ojonga ukuthotyelwa kwayo nayiphi na imigangatho yokuvelisa.

22:43.051 --> 22:45.860
Inkqubo ye-WHO sisoyikiso kuluntu.

22:45.860 --> 22:49.346
Iwusongela WENA nabo ubathandayo.

22:49.346 --> 22:56.453
Bantu behlabathi, manyanani nisisindise kule ntsila yobugebenga!

22:56.453 --> 23:03.890
Masiyeke izitofu ze-mRNA – masiyeke i-WHO!

23:13.921 --> 23:19.759
Molo, igama lam ndinguLara kwaye
namhlanje ndiza kunixelela ibali lam.

23:19.759 --> 23:21.290
Igama lam ndinguLara.

23:21.290 --> 23:24.848
Igama lam ndinguLara, kwaye ndibe neminyaka
engamashumi amabini kwinyanga ephelileyo.

23:24.848 --> 23:30.215
Igama lam ndinguLara, ndineminyaka engamashumi amabini ubudala,
kwaye kwiiveki ezimbini phambi komhla wam wokuzalwa weshumi

23:30.215 --> 23:34.063
elinesibhozo, ndalahlekelwa ngesiquphe ngamandla okuhamba.

23:34.063 --> 23:42.943
Kwiintsuku ezintathu emva kokufumana isitofu sam sesithathu
se-coronavirus ngomhla we-17 kaJanuwari 2022, ndaye ndatyhafa.

23:42.943 --> 23:52.431
Xa ndaphaphama, ndandibhideke ngokupheleleyo kwaye imilenze
yam yayingasakwazi ukundixhasa. Ndingasakwazi nje ukuhamba.

23:52.431 --> 23:55.931
Andisokuze ndiyilibale le mhla kungekudala.

23:55.931 --> 24:03.188
Emva kweyure, nam ndiye ndaqala ukufumana ubunzima
bokuphefumla, ndaza ndasiwa kwisibhedlele sabantwana.

24:03.188 --> 24:05.063
Ewe.

24:07.345 --> 24:12.260
Kwixesha elalandelayo, imeko yam ayizange itshintshe kakhulu.

24:12.260 --> 24:15.758
Nezandla zam bezingakwazi ukubamba izinto kakuhle.

24:15.758 --> 24:18.243
Ndichithe iintsuku zam ndilele ebhedini.

24:18.243 --> 24:25.149
Ukufunda kwakungenakwenzeka kuba ngesigama sesithathu
kwisivakalisi, ndandisele ndilibele amagama amabini okuqala...

24:26.657 --> 24:30.092
Umculo neevidiyo bezindigcina ndingodwa.

24:30.092 --> 24:35.217
Kwongezwa ukungakwazi ukuzibamba, igama ebendingalazi nokulazi.

24:35.217 --> 24:39.060
Ndandivalelwe ebhedini iinyanga ezine.

24:39.060 --> 24:41.451
Ndandisandul' ukuba neminyaka elishumi elinesibhozo.

24:41.451 --> 24:48.120
Kum, elo beliya kuba lixesha lokuphuma,
ndidibane nabahlobo, ndonwabele inkululeko yam.

24:48.120 --> 24:51.273
Kodwa bendibotshelelwe ebhedini.

24:51.273 --> 24:54.648
Abahlobo bavalelise omnye emva komnye.

24:54.648 --> 25:02.408
Kwelinye icala, kundivisa ubuhlungu kakhulu, kodwa
kwelinye icala, wenzeni ngomntu ohlala nje ethe saa ekhaya?

25:02.408 --> 25:06.135
Andikwazi ukuzicacisela yonke le nzame ilandelileyo.

25:06.135 --> 25:08.593
Kungagqitha eli xesha.

25:08.593 --> 25:12.197
Ndiza kuyichaza ngamagama angundoqo.

25:12.197 --> 25:15.619
I-acupuncture indibuyisele ezinyaweni.

25:15.619 --> 25:17.860
Ndiphinda unyaka esikolweni.

25:17.860 --> 25:23.150
Ndiya kuhamba iihambo ezimbini
ezimfutshane, eParis naseRoma. Halala!

25:23.150 --> 25:29.096
Kodwa ngoSeptemba 2022... Kudimala ubunzima obunzulu.

25:29.096 --> 25:31.330
Ukuqalisa kwakhona kuyaqala.

25:31.330 --> 25:33.486
Andisakwazi ukuya kwakhona.

25:33.486 --> 25:37.273
Ndizama ukuphinda iklasi. Ayisebenzi.

25:37.273 --> 25:39.391
Ukutsho iintlobo zezikolo, kulungile.

25:39.391 --> 25:40.953
Akusekho ikholeji yefom yesithandathu.

25:40.953 --> 25:42.740
Kodwa utshintsho lulungile.

25:42.740 --> 25:48.462
Ndiza kufumana izikwekwetshu ukuze
ndikwazi ukuya esikolweni nakwiintsuku ezimbi.

25:48.462 --> 25:54.174
Kuqala ixesha lokuphindaphinda
koko kubizwa ngokuba kukuphinda uwe.

25:54.174 --> 25:58.720
Iinkqubo azisandi nceda kuba sendidiniwe kakhulu ngazo.

25:58.720 --> 26:04.727
Kufuneka ndamkele into
endingazange ndiyifune: isitulo esinamavili.

26:04.727 --> 26:06.965
Kodwa ndiyakwazi ukuya esikolweni.

26:06.965 --> 26:10.987
Emva koko ndaphila ngendlela yokuphinda ndiwele.

26:10.987 --> 26:14.404
Ngoku sendifunde ukuphila nokuphinda ndiwele.

26:14.404 --> 26:20.075
Ukusukela ngaloo mini kaJanuwari 2022, ubomi
bam bebunje njengohambo oluzantsi naphakathi:

26:20.075 --> 26:26.948
Ukuphinda, ikhefu, ukuphinda
okungaphelelanga, ikhefu, ukuphinda okukhulu, ikhefu.

26:26.948 --> 26:31.335
Akululanga. Kodwa ndiyakwazi ukukwenza. Ndifuna ukukwenza.

26:31.335 --> 26:33.862
Ndinephupha ezininzi.

26:33.862 --> 26:40.086
Kule minyaka mibini idlulileyo, bendixakeke
kakhulu yinto enokubonakala ingabalulekanga.

26:40.086 --> 26:42.134
Bendingazi ukuba ndinantoni.

26:42.134 --> 26:43.959
Akukho mntu wayesazi.

26:43.959 --> 26:50.168
Ndiyayikhumbula loo mini umama wam afumanisa ngayo
kwi-intanethi ukuba isifo sam esingenagama sasinayo

26:50.168 --> 26:53.880
nayo igama: i-Post-Vac Syndrome, i-Post-Vac Syndrome.

26:53.880 --> 26:58.335
Ngoku ndingahleka ngayo. Kuba ayilotyathanga ngokwenene.

26:58.335 --> 27:00.020
Kodwa ndandiyonwabile.

27:00.020 --> 27:02.638
Ngoku ndiyazi ukuba kutheni ibibaluleke kangaka kum.

27:02.638 --> 27:08.300
Kuba umntu othile wayendibonile
ngequbuliso. Kwaye imeko yam yayinesigama.

27:08.300 --> 27:11.537
Kuba ndabelane nabanye ngesigulo sam.

27:11.537 --> 27:13.312
Bendingasadidwa.

27:13.312 --> 27:15.946
Kwaye kwandikhulula.

27:15.946 --> 27:23.257
Emva kweemvavanyo ezininzi, ezazisoloko ziphela ngokuba
"yonke into iqhelekile," ekugqibeleni ndifunyaniswe ndinezi zifo

27:23.257 --> 27:27.934
zimbini: i-small fibre neuropathy kunye ne-fatigue syndrome.

27:27.934 --> 27:34.200
Kolu hambo lude, andifumananga kuphela
amava amabi ngononophelo lwezempilo.

27:34.200 --> 27:36.580
Oogqirha abambalwa babesenza izigqibo.

27:36.580 --> 27:41.752
Undincedile ukuba ndiqhubele phambili kancinci,
kwaye ndiyakubulela ukusuka ezantsi zentliziyo yam.

27:41.752 --> 27:43.873
Ndisemgibeni onyukayo we-roller coaster.

27:43.873 --> 27:45.780
Akukapheli.

27:45.780 --> 27:47.700
Kodwa ngoku sele ithe tyaba.

27:47.700 --> 27:49.003
Ndiyathemba ukuba kuya kuhlala kunjalo.

27:49.003 --> 27:53.264
Kwaye ndinethemba lokuba ngenye imini ndiza
kukwazi ukuphuma kule rollercoaster ngokupheleleyo.

27:53.264 --> 27:58.699
Kungakuhle ukuma emhlabeni ngemilenze yam esebenzayo.

27:58.699 --> 28:00.730
Qhubeka nokuphanda!

28:00.730 --> 28:08.476
Sonke sidinga umbono. Kwaye ndikudinga wena. Enkosi.

28:11.867 --> 28:18.268
Umbutho we-MWGFD wenze udliwano-ndlebe olongezelelweyo
oluchukumisayo nolubambekayo nabantu abonzakaliswe ziigonyo

28:18.268 --> 28:22.273
ze-mRNA kuthotho oluthi "bagonyiwe, bonzakaliswe, baphikiswe".

28:22.273 --> 28:25.740
Ungazifumana ezi phantsi kwekhonkco elibonisweyo.

28:25.740 --> 28:32.449
Ngenxa yokuba itekhnoloji ye-mRNA iza kusetyenziswa nakwezinye
iinjongo zokugonya – okanye, ukuthetha ngokuchanekileyo,

28:32.449 --> 28:39.118
kunyango lwemfuza – kubaluleke ngakumbi ukwazisa
uluntu ngezi ngxelo zothuso ngomonakalo owenziwa yivayisi.

28:39.118 --> 28:42.797
Nceda uzive ukhululekile ukwabelana ngezi dili.

28:42.797 --> 28:50.346
Ungancedisa kwakhona ekukhanyiseni ubungakanani
bomonakalo obubangelwa ziigonyo ze-mRNA ngokuxela nawuphi na

28:50.346 --> 28:54.120
umonakalo wogonyo kwingingqi yakho kwi-vetopedia.org.