WEBVTT 00:00.726 --> 00:06.015 Nge-coronavirus, kuye kwaziswa itekhnoloji entsha yokugonya, i-mRNA technology. 00:06.015 --> 00:12.524 Kubalulekile ukuqonda ukuba olu phuhliso lwe-mRNA ayizizo izitofu zokugonya ngokwentsingiselo yesiqhelo. 00:12.524 --> 00:19.973 Abantu abafakwa ipathogen ebuthathaka nengenabungozi ekuthiwa ivuselela inkqubo yokhuselo lomzimba, kodwa 00:19.973 --> 00:27.499 endaweni yoko bafakwa ikhowudi yemfuza enyanzela iiseli zesigulana ukuba zivelise iiproteni ezintsha. 00:27.499 --> 00:34.207 Yiyo le nto ukugonya nge-mRNA kukwabizwa ngokuba kukutofwa kwegene ye-mRNA okanye unyango lwegene. 00:34.207 --> 00:40.700 I-mRNA enikwa ngesirinji ifakwe kwisongelo esincinci esisangqa esenziwe ngamaleko amabini e-lipid . 00:40.700 --> 00:49.283 Ezi nanoparticles ze-lipid, okanye ii-LNPs ngokufutshane, zenza i-mRNA ikwazi ukungena kwiseli. 00:49.283 --> 00:54.943 I-Moderna ne-BioNTech ziinkampani ezimbini zamachiza ezizabelo zazo zithengiswa kwishishini lezabelo. 00:54.943 --> 00:59.060 Benze iibhiliyoni zenzuzo ngexesha lobhubhane we-coronavirus. 00:59.060 --> 01:05.371 Nangona yayiphantsi kwemvume kwexakeka kuphela, izinto ze-mRNA ziye zatyhilwa ebantwini ngobuninzi kumazwe 01:05.371 --> 01:09.737 amaninzi ukususela malunga noDisemba 2020 ukuza kuthi ga ngoku. 01:09.737 --> 01:16.516 Ishishini lamachiza lalahlekisa uluntu ngokuthi esi siqhushumbisi segene esichasene ne-coronavirus i-SARS-CoV-2 01:16.516 --> 01:20.673 sikhuselekile, siyancedayo kwaye asinampawu zingalunganga. 01:20.673 --> 01:27.764 Amalizwi ogxeko nolumkiso ahlaziswa, acinezelwa, ahlukunyezwa kwaye atshabalaliswa ngokwezoqoqosho. 01:27.764 --> 01:36.253 Ngokwahluka okukhulu, uGqr. Sabine Stebel ukhomba kwiphephancwadi lakhe leendaba elithi "DrBine's" kwinqaku elithi "Awunakuxokisa 01:36.253 --> 01:43.228 kwimarike yezabelo (ngokungafaniyo nezigulana noorhulumente)" elinomhla wesi-4 kuMeyi 2025, oko i-BioNTech 01:43.228 --> 01:48.514 ne-Moderna ezivumileyo kwimarike yezabelo kwiingxelo zazo. 01:48.514 --> 01:56.010 I-BioNTech ne-Moderna ngabavelisi beentlobo zomthamo wokugonya we-mRNA we-coronavirus, ezizezi i-Comirnaty® ne-Spikevax®. 01:56.010 --> 02:03.854 Ngo-2018, iModerna yabhala oku kulandelayo kwingxelo yayo yemarike yezabelo kubanini-zabelo bayo njengabatyali-mali: 02:03.854 --> 02:10.327 "Uninzi lweemveliso zethu zophando ziyilwa kwaye zisetyenziswe njenge-LNP , nangona siye saziphucula ngakumbi 02:10.327 --> 02:17.617 ii-LNPs zethu, akukho siqinisekiso sokuba ii-LNPs zethu aziyi kuba naziphi na iziphumo ebezingalindelekanga." 02:17.617 --> 02:23.477 Iziphendlo zokhuselo lomzimba, iziphendlo zokufakwa kwegazi, iziphendlo ze-complement, iziphendlo ze-antibody. 02:23.477 --> 02:28.692 Uninzi lwezi ntlobo zeziphumo ebezingalindelekanga sele ziboniwe kwii-LNPs zangaphambili. 02:28.692 --> 02:35.343 Ukuba kubonwa iziganeko ezibi ezibalulekileyo okanye ezinye iziphumo ebezingalindelekanga kuzo naziphi na iimvavanyo 02:35.343 --> 02:42.786 zethu zeklinikhi eziqhubekayo okanye ezizayo, sinokuba nobunzima bokufumana abathathi-nxaxheba kwiimvavanyo zethu zeklinikhi. 02:42.786 --> 02:48.575 okanye sinokunyanzeleka ukuba siyeke izifundo okanye iinzame zethu zophuhliso ngokupheleleyo. 02:48.575 --> 02:54.263 Nokuba iziphumo ebezingalindelekanga azithinteli iyeza ekufumaneni okanye ekugcineni imvume yokuthengisa, 02:54.263 --> 03:00.846 umlinganiselo ongathandekiyo wenzuzo nomngcipheko unokuchaphazela ukwamkelwa kwemveliso evunyiweyo kwimarike. 03:00.846 --> 03:05.114 Naphi na kule mihlahlandlela inokuba nefuthe elibi elibonakalayo kwishishini lethu, kwimeko 03:05.114 --> 03:08.069 yethu yezemali nakwizibono zethu zexesha elizayo. 03:08.069 --> 03:14.578 Ekupheleni kuka-2021, emva kokuba isitofu sokugonya se-mRNA sifumene imvume yokuthengisa enemiqathango kwaye 03:14.578 --> 03:21.605 sasisele sinikwe izigidi ngezigidi zabantu, iModerna ngokumangalisayo iphinde yaphinda iingxelo zayo zangaphambili. 03:21.605 --> 03:26.386 I-BioNTech ibhala into efanayo malunga nesitofu sayo se-mRNA i-Comirnaty® kwingxelo 03:26.386 --> 03:29.580 yayo yemarike yezabelo ekupheleni kuka-2019: 03:29.580 --> 03:36.702 "Iimveliso zethu ezisacetywayo zisenokungasebenzi njengoko bekucetyiwe, zibangele iziphumo ebezingalindelekanga, okanye 03:36.702 --> 03:43.344 zibonise ezinye iimpawu ezinokuthi zibambe okanye zithintele ukwamkelwa kwazo, zinciphise ukuthengiseka komuthi 03:43.344 --> 03:50.940 osele wamkelwe, okanye zikhokelele kwiziphumo ezibi ezibalulekileyo emva kokwamkelwa kwimarike, ukuba zikhona." 03:50.940 --> 03:58.333 Ingxelo ye-BioNTech ka-2022 ithi: "Iimveliso esiziphuhlisa zisenokungasebenzi kakuhle, okanye zisebenze kancinci nje, okanye 03:58.333 --> 04:04.414 zibe neziphumo ebezingalindelekanga ezingathandekiyo okanye ezingajongwanga, ubungendawo okanye ezinye 04:04.414 --> 04:10.395 iimpawu ezinokuthintela ukwamkelwa kwimarike okanye zinciphise ukusetyenziswa kwezorhwebo." 04:10.395 --> 04:16.697 Emva kweminyaka emibini yovavanyo olubanzi kwizigidi zezizigidi zabantu kwihlabathi jikelele, akufanelanga na ukuba 04:16.697 --> 04:19.543 umbuzo wokusebenza kakuhle nokhuseleko ucacisiwe kudala? 04:19.543 --> 04:24.766 Kodwa hayi, kwanangokuphela kuka-2023, lo mbuzo kusenokwenzeka ukuba usazakuba ungasonjululwanga, 04:24.766 --> 04:28.333 njengoko i-BioNTech ibhale kwingxelo yayo yonyaka: 04:28.333 --> 04:35.994 "Sisenokungakwazi ukubonisa ukusebenza ngokwaneleyo okanye ukukhuseleka kwesitofu sethu se-COVID-19 ukuze sifumane 04:35.994 --> 04:44.636 imvume esisigxina kumazwe apho sivunyiwe khona kusetyenziso lwexeshana okanye sifumene imvume yokuthengisa enemiqathango." 04:44.636 --> 04:51.463 Ingxelo yonyaka ka-2024 ye-BioNTech ithi: "Sifumene amabango okubangela umonakalo ngenxa yomveliso ngokuchasene nesitofu 04:51.463 --> 04:58.620 sethu se-COVID-19 kwaye silindele ukufumana amanye amabango okubangela umonakalo ngenxa yomveliso kwixesha elizayo." 04:58.620 --> 05:06.443 Ukuba asikwazi ukuzithethelela ngempumelelo kwizimangalo zokuba iimveliso zethu kunye/okanye iimveliso esizilingayo 05:06.443 --> 05:11.198 zibangele umonakalo, sinokuba neembopheleleko ezinkulu. 05:11.198 --> 05:16.701 Ezi ngxelo zemarike yezabelo ezivela kwa-Moderna nakwa-BioNTech ziyangqina kwakhona indlela abantu abaxhatshazwe ngayo 05:16.701 --> 05:22.671 ngokungekho sikweni, beqhathwe ngabom, bebaxokiswa kwaye belawulwa ngenkohliso lishishini lamachiza, oosopolitiki kunye namajelo 05:22.671 --> 05:26.173 eendaba, ukuba bathathe inxaxheba kule mivavanyo yezonyango. 05:26.173 --> 05:33.205 Nangona zombini ezi nkampani zazichaze esidlangalaleni ukuba izitofu zokugonya ze-mRNA zinokubangela iziphumo 05:33.205 --> 05:37.506 ebezingalindelekanga ezibonakalayo, oku kwafihlwa eluntwini. 05:37.506 --> 05:41.475 Kwakukho into enye kuphela eyayicacile ukuba ibalulekile kwaye iyagqiba: 05:41.475 --> 05:47.473 Ingeniso nokuba kuthini na! Nokuba ixabiso liyintoni na, nkqu nobomi babantu! 05:47.473 --> 05:51.695 Njengoko ezi zizimvume ezingxamisekileyo zezitofu zokugonya, abavelisi abanyanzelekanga nokuba 05:51.695 --> 05:54.559 bazihlawulele iindleko zomonakalo obangelwa zizitofu. 05:54.559 --> 05:59.752 Izigaba ezihambelanayo zoxanduva zafakwa kwiikhontrakthi nabavelisi begama. 05:59.752 --> 06:03.744 Oku kungenxa yobume obusemthethweni bemvume zongxamiseko. 06:03.744 --> 06:10.349 Iilizwe ze-EU, umzekelo, zibuyekeza abavelisi lwezitofu zokugonya i-COVID-19 ukuba zithwaliswa uxanduva 06:10.349 --> 06:13.406 lweziphumo ebezingalindelekanga ezifunyanwa zizigulana. 06:13.406 --> 06:22.195 Ngamanye amazwi, ngabantu abakhohlisiweyo nabonzakaliswayo ekufuneka bahlawule oku ngerhafu yabo. 06:22.195 --> 06:28.111 Ngaba uziva ukudimazeka, umsindo okanye ezinye iimvakalelo xa ujongene nobuqhophololo nobuxoki obunje obuchasene nabantu? 06:28.111 --> 06:35.703 Zibandakanye nababhali-ndaba abaphandlayo ukuze uveze ubuxoki nobuqhophololo. 06:35.703 --> 06:38.686 I-Kla.tv isekelwe kumsebenzi wokuzithandela. 06:38.686 --> 06:42.679 Yiba yinxalenye yentshukumo yezemfundo enkulu kunawo onke yeli xesha lethu ngoku! 06:42.679 --> 06:48.005 www.kla.tv/mitwirken 06:50.708 --> 06:54.346 Siyadinga! 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