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Nge-coronavirus, kwethulwe ubuchwepheshe
bokugoma obusha, ubuchwepheshe be-mRNA.

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Kubalulekile ukuqonda ukuthi lezi zintuthuko
ze-mRNA aziyona imijovo yokugoma ngokwesiko.

4
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Abantu abafakwa umjovo ongenayo ipathogeni ebuthakathaka
nengalimazi okuthiwa ivusa uhlelo lwabo lokuzivikela

5
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komzimba, kodwa kunalokho bafakwa ikhodi yemfuzo
ephoqa amaseli womguli ukuthi akhiqize amaprotheni amasha.

6
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Yingakho umjovo we-mRNA ubizwa nangokuthi
ukufakwa kwegene ye-mRNA noma ukwelashwa kwegene.

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I-mRNA enikezwa ngesirinji ifakwe ngaphakathi
kwesendlalelo esincane esiyindilinga esenziwe ngama-lipid .

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Lezi nanoparticles zamafutha, noma ama-LNPs
ngokufingqiwe, zivumela i-mRNA ukuthi ingene eselini.

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00:00:49,283 --> 00:00:54,943
I-Moderna ne-BioNTech yizinkampani ezimbili
zemithi ezinezabelo ezithengiswa emakethe yamasheya.

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Benze izigidigidi zenzuzo ngesikhathi sobhubhane lwe-coronavirus.

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Nakuba kwakugunyazwe kuphela esimweni esiphuthumayo,
izinto ze-mRNA zafakwa emzimbeni wabantu ngobuningi

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emazweni amaningi kusukela cishe ngoDisemba 2020 kuqhubeke.

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Umkhakha wezokwelapha walahambisa umphakathi ngokuthi lo
jovo weli jinomu elwa ne-coronavirus i-SARS-CoV-2

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liphephile, lisebenza kahle futhi alinazo iziphumo ezingezinhle.

15
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Izwi labagxeki nezokuxwayisa lagcwaliswa udumo olubi,
lavinjelwa, lahlukunyezwa futhi labhujiswa ngokwezimali.

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Ngokuphambene ngokuphelele, uDkt. Sabine Stebel ukhomba encwadini
yakhe yezindaba ethi "DrBine's" esihlokweni esithi "Awukwazi

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00:01:35,863 --> 00:01:43,384
ukukhohlisa imakethe yamasheya (hhayi njengokukhohlisa
iziguli nohulumeni)" osuku lwango-4 Meyi 2025, lokho iBioNTech

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neModerna abakuvumile emakethe yamasheya emibikweni yabo.

19
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I-BioNTech ne-Moderna bangabakhiqizi bemithi yokugoma
ye-mRNA ye-coronavirus, okungukuthi i-Comirnaty® ne-Spikevax®.

20
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Ngonyaka ka-2018, iModerna yabhala okulandelayo embikweni wayo
wemakethe yamasheya kubaninimasheya bayo njengabatshalizimali:

21
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Iningi lemikhiqizo yethu yokucwaninga liyakhiwa futhi linikezwa
ngaphakathi kwe-LNP , nakuba sesithuthukise

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kakhulu ama-LNP ethu, akukho siqinisekiso sokuthi
ama-LNP ethu ngeke abe nemiphumela engemihle.

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Iziphendulo zokuzivikela komzimba, iziphendulo zokufakwa
ketshezi, iziphendulo ze-complement, iziphendulo zamabhowudi.

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Iningi lezi zinhlobo zemiphumela
engemihle sezibonwe ngaphambilini kuma-LNPs.

25
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Uma kwenzeka izigameko ezimbi ezibalulekile noma ezinye
imiphumela engemihle kuzo zonke izilingo zethu

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zokwelapha eziqhubekayo noma ezizayo, singase sibe
nobunzima ekuqasheni abahlanganyeli kulezi zilingo zethu.

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noma singase siphoqeleke ukuyeka ngokuphelele
izifundo noma imizamo yethu yokuthuthukisa.

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Noma ngabe imiphumela engemihle ayivimbi umuthi ekutholeni noma
ekugcineni imvume yokumaketha, isilinganiso

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esingezinhle sezinzuzo nengozi singathinta
ukwamukelwa kwemakethe komkhiqizo ovunyelwe.

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Noma yiziphi zalezi zintuthuko zingaba nomthelela
omubi obonakalayo ebhizinisini lethu, esimweni

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sethu sezimali nasemikhakheni yethu yezokuthuthuka.

32
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Ekupheleni kuka-2021, ngemva kokuthi umuthi wokugoma we-mRNA
wathola imvume yokumaketha enezimo futhi

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usuwunikezwe izigidi zamahlandla, iModerna
ngokumangazayo yaphinda izitatimende zayo zangaphambilini.

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00:03:21,605 --> 00:03:26,430
I-BioNTech ibhala okufanayo mayelana nomuthi
wayo wokugoma we-mRNA i-Comirnaty® embikweni

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wayo wemakethe yamasheya ekupheleni kuka-2019:

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"Abafakisicelo bethu bemikhiqizo bangase bangasebenzi njengoba
bekulindelekile, bangadala imiphumela engemihle engafuneki, noma

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babonise ezinye izimfanelo ezingabambezela noma ezivimbe
ukuvunywa kwazo, banciphise iphrofayili yokuhweba

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komuthi ovunyiwe, noma kuholele emiphumeleni engemihle
ebalulekile ngemva kokuvunywa emakethe, uma kukhona."

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Umbiko we-BioNTech ka-2022 uthi: "Imikhiqizo esiyithuthukisayo
ingase ingasebenzi kahle noma isebenze kancane kuphela, noma

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ingaba nemiphumela engemihle noma engalindelekile,
ubuthi noma ezinye izici ezingavimbela ukuvunywa

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emakethe noma zinciphise ukusetshenziswa kwayo kwezohwebo."

42
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Ngemva kweminyaka emibili yokuhlolwa okuningi kubantu
abayizigidigidi emhlabeni wonke, akufanele yini ukuthi

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umbuzo wokusebenza kahle nokuphepha ucacisiwe kudala?

44
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Kodwa cha, ngisho ekupheleni kuka-2023, kungenzeka
ukuthi lo mbuzo usazoba ngaphandle

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kokuxazululeka, ngoba i-BioNTech yabhala embikweni wayo wonyaka:

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Kungenzeka singakwazi ukukhombisa ukusebenza ngokwanele noma
ukuphepha kwemithi yethu yokugoma i-COVID-19 ukuze sithole

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ukuvunywa okungapheli emazweni lapho
kuvunyelwe khona ukusetshenziswa okuphuthumayo noma

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lapho ithole khona imvume yokumaketha enezimo.

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Umbiko wonyaka ka-2024 we-BioNTech uthi: "Sithole izimangalo
zomthwalo wemvelo womkhiqizo mayelana nesitofu sethu

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se-COVID-19 futhi silindele ukuthola ezinye
izimangalo zomthwalo wemvelo womkhiqizo esikhathini esizayo."

51
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Uma singakwazi ukuzivikela ngempumelelo ezimangweni zokuthi
imikhiqizo yethu kanye/noma izinto ezingase zibe imikhiqizo

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00:05:06,353 --> 00:05:11,198
yethu zibangele umonakalo, singase sibe nezibopho ezinkulu.

53
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Le mibiko yemakethe yamasheya evela kwaModerna nakuBioNTech
iphinde ifakazele ukuthi abantu bagqekeziwe ngokungahloniphi,

54
00:05:17,233 --> 00:05:22,670
baxoxwa amanga futhi baphathwa ngobuqili yimboni
yezemithi, abezepolitiki kanye neziteshi zezindaba ngenhloso

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yokubabamba bahlanganyele kulezi zivivinyo zezokwelapha.

56
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Nakuba zombili izinkampani zaveza obala ukuthi
imijovo yokugoma ye-mRNA ingabangela imiphumela

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emibi ebalulekile, lokhu kwafihlwa emphakathini.

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Kwakukhona into eyodwa kuphela
eyayibalulekile futhi eyayinqumayo:

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Inzuzo nganoma yiziphi izindleko! Noma
yini intengo, ngisho nezimpilo zabantu!

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Njengoba lezi zivunyelwe eziphuthumayo
zamavayisini, abakhiqizi abadingeki ngisho

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nokukhokhela izindleko zokulimala okubangelwa yimivayisi.

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Izigaba zemithwalo yemfanelo ezihambisanayo
zafakwa ezinkontilekeni nabakhiqizi bemithi yokugoma.

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Lokhu kungenxa yemvelo esemthethweni yokugunyazwa okuphuthumayo.

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Izizwe ze-EU, isibonelo, zibuyisela abakhiqizi
bemithi yokugoma i-COVID-19 imali uma zibophezelwa

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ngemiphumela engemihle abaguli abayihlangabezane nayo.

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Ngamanye amazwi, yibo abantu abakhohlisiwe
nabalimele abazokhokha lokhu ngentela yabo.

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Uzizwa udangele, uthukuthele noma uneminye imizwa lapho
ubhekene nalolu buqili nobugebengu obuqondiswe kubantu?

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Hlanganyela emigqeni yababalobi
bophenyo bese uveze amanga nokukhohlisa.

69
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Kla.tv isekelwe emsebenzini wokuzithandela.

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Yiba yingxenye yomzamo wemfundo omkhulu
kunayo yonke kwesikhathi sethu manje!

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www.kla.tv/mitwirken

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Siyakudinga! I-Kla.tv ifuna abavolontiya.