WEBVTT 00:00.726 --> 00:06.015 Nge-coronavirus, kwethulwe ubuchwepheshe bokugoma obusha, ubuchwepheshe be-mRNA. 00:06.015 --> 00:12.524 Kubalulekile ukuqonda ukuthi lezi zintuthuko ze-mRNA aziyona imijovo yokugoma ngokwesiko. 00:12.524 --> 00:19.900 Abantu abafakwa umjovo ongenayo ipathogeni ebuthakathaka nengalimazi okuthiwa ivusa uhlelo lwabo lokuzivikela 00:19.900 --> 00:27.499 komzimba, kodwa kunalokho bafakwa ikhodi yemfuzo ephoqa amaseli womguli ukuthi akhiqize amaprotheni amasha. 00:27.499 --> 00:34.207 Yingakho umjovo we-mRNA ubizwa nangokuthi ukufakwa kwegene ye-mRNA noma ukwelashwa kwegene. 00:34.207 --> 00:40.700 I-mRNA enikezwa ngesirinji ifakwe ngaphakathi kwesendlalelo esincane esiyindilinga esenziwe ngama-lipid . 00:40.700 --> 00:49.283 Lezi nanoparticles zamafutha, noma ama-LNPs ngokufingqiwe, zivumela i-mRNA ukuthi ingene eselini. 00:49.283 --> 00:54.943 I-Moderna ne-BioNTech yizinkampani ezimbili zemithi ezinezabelo ezithengiswa emakethe yamasheya. 00:54.943 --> 00:59.060 Benze izigidigidi zenzuzo ngesikhathi sobhubhane lwe-coronavirus. 00:59.060 --> 01:05.469 Nakuba kwakugunyazwe kuphela esimweni esiphuthumayo, izinto ze-mRNA zafakwa emzimbeni wabantu ngobuningi 01:05.469 --> 01:09.737 emazweni amaningi kusukela cishe ngoDisemba 2020 kuqhubeke. 01:09.737 --> 01:16.173 Umkhakha wezokwelapha walahambisa umphakathi ngokuthi lo jovo weli jinomu elwa ne-coronavirus i-SARS-CoV-2 01:16.173 --> 01:20.673 liphephile, lisebenza kahle futhi alinazo iziphumo ezingezinhle. 01:20.673 --> 01:27.764 Izwi labagxeki nezokuxwayisa lagcwaliswa udumo olubi, lavinjelwa, lahlukunyezwa futhi labhujiswa ngokwezimali. 01:27.764 --> 01:35.863 Ngokuphambene ngokuphelele, uDkt. Sabine Stebel ukhomba encwadini yakhe yezindaba ethi "DrBine's" esihlokweni esithi "Awukwazi 01:35.863 --> 01:43.384 ukukhohlisa imakethe yamasheya (hhayi njengokukhohlisa iziguli nohulumeni)" osuku lwango-4 Meyi 2025, lokho iBioNTech 01:43.384 --> 01:48.514 neModerna abakuvumile emakethe yamasheya emibikweni yabo. 01:48.514 --> 01:56.010 I-BioNTech ne-Moderna bangabakhiqizi bemithi yokugoma ye-mRNA ye-coronavirus, okungukuthi i-Comirnaty® ne-Spikevax®. 01:56.010 --> 02:03.854 Ngonyaka ka-2018, iModerna yabhala okulandelayo embikweni wayo wemakethe yamasheya kubaninimasheya bayo njengabatshalizimali: 02:03.854 --> 02:10.709 Iningi lemikhiqizo yethu yokucwaninga liyakhiwa futhi linikezwa ngaphakathi kwe-LNP , nakuba sesithuthukise 02:10.709 --> 02:17.617 kakhulu ama-LNP ethu, akukho siqinisekiso sokuthi ama-LNP ethu ngeke abe nemiphumela engemihle. 02:17.617 --> 02:23.477 Iziphendulo zokuzivikela komzimba, iziphendulo zokufakwa ketshezi, iziphendulo ze-complement, iziphendulo zamabhowudi. 02:23.477 --> 02:28.692 Iningi lezi zinhlobo zemiphumela engemihle sezibonwe ngaphambilini kuma-LNPs. 02:28.692 --> 02:35.399 Uma kwenzeka izigameko ezimbi ezibalulekile noma ezinye imiphumela engemihle kuzo zonke izilingo zethu 02:35.399 --> 02:42.786 zokwelapha eziqhubekayo noma ezizayo, singase sibe nobunzima ekuqasheni abahlanganyeli kulezi zilingo zethu. 02:42.786 --> 02:48.575 noma singase siphoqeleke ukuyeka ngokuphelele izifundo noma imizamo yethu yokuthuthukisa. 02:48.575 --> 02:54.965 Noma ngabe imiphumela engemihle ayivimbi umuthi ekutholeni noma ekugcineni imvume yokumaketha, isilinganiso 02:54.965 --> 03:00.846 esingezinhle sezinzuzo nengozi singathinta ukwamukelwa kwemakethe komkhiqizo ovunyelwe. 03:00.846 --> 03:05.136 Noma yiziphi zalezi zintuthuko zingaba nomthelela omubi obonakalayo ebhizinisini lethu, esimweni 03:05.136 --> 03:08.069 sethu sezimali nasemikhakheni yethu yezokuthuthuka. 03:08.069 --> 03:14.766 Ekupheleni kuka-2021, ngemva kokuthi umuthi wokugoma we-mRNA wathola imvume yokumaketha enezimo futhi 03:14.766 --> 03:21.605 usuwunikezwe izigidi zamahlandla, iModerna ngokumangazayo yaphinda izitatimende zayo zangaphambilini. 03:21.605 --> 03:26.430 I-BioNTech ibhala okufanayo mayelana nomuthi wayo wokugoma we-mRNA i-Comirnaty® embikweni 03:26.430 --> 03:29.580 wayo wemakethe yamasheya ekupheleni kuka-2019: 03:29.580 --> 03:37.180 "Abafakisicelo bethu bemikhiqizo bangase bangasebenzi njengoba bekulindelekile, bangadala imiphumela engemihle engafuneki, noma 03:37.180 --> 03:43.524 babonise ezinye izimfanelo ezingabambezela noma ezivimbe ukuvunywa kwazo, banciphise iphrofayili yokuhweba 03:43.524 --> 03:50.940 komuthi ovunyiwe, noma kuholele emiphumeleni engemihle ebalulekile ngemva kokuvunywa emakethe, uma kukhona." 03:50.940 --> 03:59.206 Umbiko we-BioNTech ka-2022 uthi: "Imikhiqizo esiyithuthukisayo ingase ingasebenzi kahle noma isebenze kancane kuphela, noma 03:59.206 --> 04:05.859 ingaba nemiphumela engemihle noma engalindelekile, ubuthi noma ezinye izici ezingavimbela ukuvunywa 04:05.859 --> 04:10.395 emakethe noma zinciphise ukusetshenziswa kwayo kwezohwebo." 04:10.395 --> 04:16.678 Ngemva kweminyaka emibili yokuhlolwa okuningi kubantu abayizigidigidi emhlabeni wonke, akufanele yini ukuthi 04:16.678 --> 04:19.543 umbuzo wokusebenza kahle nokuphepha ucacisiwe kudala? 04:19.543 --> 04:24.059 Kodwa cha, ngisho ekupheleni kuka-2023, kungenzeka ukuthi lo mbuzo usazoba ngaphandle 04:24.059 --> 04:28.333 kokuxazululeka, ngoba i-BioNTech yabhala embikweni wayo wonyaka: 04:28.333 --> 04:35.766 Kungenzeka singakwazi ukukhombisa ukusebenza ngokwanele noma ukuphepha kwemithi yethu yokugoma i-COVID-19 ukuze sithole 04:35.766 --> 04:41.262 ukuvunywa okungapheli emazweni lapho kuvunyelwe khona ukusetshenziswa okuphuthumayo noma 04:41.262 --> 04:44.636 lapho ithole khona imvume yokumaketha enezimo. 04:44.636 --> 04:51.593 Umbiko wonyaka ka-2024 we-BioNTech uthi: "Sithole izimangalo zomthwalo wemvelo womkhiqizo mayelana nesitofu sethu 04:51.593 --> 04:58.620 se-COVID-19 futhi silindele ukuthola ezinye izimangalo zomthwalo wemvelo womkhiqizo esikhathini esizayo." 04:58.620 --> 05:06.353 Uma singakwazi ukuzivikela ngempumelelo ezimangweni zokuthi imikhiqizo yethu kanye/noma izinto ezingase zibe imikhiqizo 05:06.353 --> 05:11.198 yethu zibangele umonakalo, singase sibe nezibopho ezinkulu. 05:11.198 --> 05:17.233 Le mibiko yemakethe yamasheya evela kwaModerna nakuBioNTech iphinde ifakazele ukuthi abantu bagqekeziwe ngokungahloniphi, 05:17.233 --> 05:22.670 baxoxwa amanga futhi baphathwa ngobuqili yimboni yezemithi, abezepolitiki kanye neziteshi zezindaba ngenhloso 05:22.670 --> 05:26.173 yokubabamba bahlanganyele kulezi zivivinyo zezokwelapha. 05:26.173 --> 05:33.382 Nakuba zombili izinkampani zaveza obala ukuthi imijovo yokugoma ye-mRNA ingabangela imiphumela 05:33.382 --> 05:37.506 emibi ebalulekile, lokhu kwafihlwa emphakathini. 05:37.506 --> 05:41.475 Kwakukhona into eyodwa kuphela eyayibalulekile futhi eyayinqumayo: 05:41.475 --> 05:47.473 Inzuzo nganoma yiziphi izindleko! Noma yini intengo, ngisho nezimpilo zabantu! 05:47.473 --> 05:51.347 Njengoba lezi zivunyelwe eziphuthumayo zamavayisini, abakhiqizi abadingeki ngisho 05:51.347 --> 05:54.559 nokukhokhela izindleko zokulimala okubangelwa yimivayisi. 05:54.559 --> 05:59.752 Izigaba zemithwalo yemfanelo ezihambisanayo zafakwa ezinkontilekeni nabakhiqizi bemithi yokugoma. 05:59.752 --> 06:03.744 Lokhu kungenxa yemvelo esemthethweni yokugunyazwa okuphuthumayo. 06:03.744 --> 06:10.251 Izizwe ze-EU, isibonelo, zibuyisela abakhiqizi bemithi yokugoma i-COVID-19 imali uma zibophezelwa 06:10.251 --> 06:13.406 ngemiphumela engemihle abaguli abayihlangabezane nayo. 06:13.406 --> 06:22.195 Ngamanye amazwi, yibo abantu abakhohlisiwe nabalimele abazokhokha lokhu ngentela yabo. 06:22.195 --> 06:28.111 Uzizwa udangele, uthukuthele noma uneminye imizwa lapho ubhekene nalolu buqili nobugebengu obuqondiswe kubantu? 06:28.111 --> 06:35.703 Hlanganyela emigqeni yababalobi bophenyo bese uveze amanga nokukhohlisa. 06:35.703 --> 06:38.686 Kla.tv isekelwe emsebenzini wokuzithandela. 06:38.686 --> 06:42.679 Yiba yingxenye yomzamo wemfundo omkhulu kunayo yonke kwesikhathi sethu manje! 06:42.679 --> 06:48.005 www.kla.tv/mitwirken 06:50.708 --> 06:54.346 Siyakudinga! 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