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Isikhalazo sobugxwayiba esichasene nePaul Ehrlich Institute

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Ngo-2025, kwapapashwa izifundo ezibini, zombini ezi
zibonise umngcipheko onyuke kakhulu womhlaza emva

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kokugonywa ngeentlobo zezijovo ezibizwa ngokuba zii-mRNA.

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00:00:12,976 --> 00:00:19,026
Emva kokuba iPaul Ehrlich Institute (PEI) enoxanduva ilile
ukuphendula ngexesha elifanelekileyo, ngokuchasene nemimiselo

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00:00:19,026 --> 00:00:25,570
yomthetho, isazi ngezakhi zophilo nengcali yamachiza uGqr. Jürgen
O. Kirchner ufake isikhalazo sokubeka iliso ngokuchasene ne-PEI.

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00:00:25,570 --> 00:00:30,324
UGqr. Kirchner ucinga ukuba umngcipheko
womhlaza unokubangelwa lulonakalo lwe-DNA

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olufunyenwe kwizincwadi ezininzi ezipapashiweyo.

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Ngenxa yobunzulu obukhulu bale nyathelo
kwimpilo yoluntu, uNjingalwazi Gqr. Sucharit

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00:00:39,013 --> 00:00:42,903
Bhakdi ubongoza inkxaso kaGqr. Kirchner kwividiyo.

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00:00:42,903 --> 00:00:47,836
Injongo kukuba i-PEI igcwalise
umsebenzi wayo owunyanzeliswe ngumthetho.

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00:00:47,836 --> 00:00:54,365
NgokukaGqr. Kirchner, abavelisi begonyo abakhululwanga kwityala
ngenxa yongcoliseko lwe-DNA, kodwa banokubekwa ityala

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00:00:54,365 --> 00:01:03,063
"lokubeka uluntu esichengeni ngokutyhefa" phantsi kweCandelo 314
loMthetho woLwaphulo-mthetho. Ngoku mamela uNjing. Gqr. Bhakdi:

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"Manenekazi nobangeni, uGqr. Jürgen Kirchner wenze
inyathelo esilithatha njengelibaluleke kakhulu

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kangangokuba singathanda ukwazisa uluntu ngokubanzi ngalo."

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Umxholo ongundoqo sisikhalazo sobugosa
esijoliswe kuMphathiswa Nina Warken.

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Ndiza kufundela esi sikhalazo sobugcini.

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UMnu Kirchner undinike imvume.

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Ukusetyenziswa kombhalo kwesikhalazo
sokongamela esincanyathiselwe kwisihlomelo

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kuxhomekeke ekuthotyelweni kwezi mfuno zilandelayo:

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Okokuqala, ubunobhala bukaMnu. Kirchner kufuneka
bukhankanywe ngokukodwa – nto leyo endiyenzayo ngoku.

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Kufuneka kuchazwe ngokucacileyo ukuba umxholo kwisikhalazo
sobugxwayiba uvela kuphando lwakhe njengombhali weencwadi.

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00:02:04,116 --> 00:02:12,896
Incwadi ekuthethwa ngayo, "Tested and Confirmed", kufuneka
ikhankanywe kwaye nesihloko sayo siboniswe ngokucacileyo.

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Umbhalo kwisikhalazo sobugcisa akufuneki utshintshwe.

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Okokugqibela, ukuba amaxwebhu adwelelekayo adityaniswe nevidiyo,
kufuneka kuqinisekiswe ukuba inguqulelo yombiko wokhexo

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olufakwe njengeNqaku lesi-2 nayo iyafumaneka ngendlela efanayo.

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Ukuba le vidiyo ijoliswe kubabukeli abangathethiyo isiJamani,
inguqulelo yesiNgesi yexela-khalazo lokongamela

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elinamathiselwe njenge-Appendix 3 kufuneka nayo
ifakwe. Sikwenza oku njengenyathelo lokulumka.

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00:02:51,170 --> 00:02:59,736
Manenekazi nobangentsi, ngoku ndiza
kufunda ileta eya kuMphathiswa Nina Warken.

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00:02:59,736 --> 00:03:07,715
Ileta ebhalisiweyo yahanjiswa ngomhla we-12 ku-Okthobha 2025

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Ingozi esondelayo: Isikhalazo sobugxwayiba esichasene nabasebenzi
be-Paul Ehrlich Institute abanoxanduva lokuqinisekisa ukuba

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izifundo ezibini ezinkulu kakhulu nezisemthethweni ze-cohort
azithathelwa ngqalelo ngendlela emiselweyo ngumthetho malunga

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nokhuseleko lwamachiza e-mRNA nezinye izitofu zokugonya ze-gene
ngokubhekiselele kwiingozi ezibalulekileyo zomhlaza, nangona oku

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kubeka isisongelo esingazange sibekho kwimpilo yoluntu eJamani.

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00:03:43,030 --> 00:03:53,568
Mhlekazi uMphathiswa, Ngomhla woku-1 kuJulayi 2025, iNcwadi
yasePescara, uphando lweqela elilindelweyo olunabathathi-nxaxheba

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abaphantse babe ngama-300,000 – bonke abahlali bephondo
lase-Itali iPescara abaneminyaka eli-11 nangaphezulu –

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yapapashwa njengopapasho lwenzululwazi oluhlolwe ngoontanga.

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Uphando luye lwaphonononga ukuba ingaba ukugonywa
ngeentsholongwane zofuzo ze-COVID-19 (iBioNTech, iModerna,

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iAstraZeneca kunye neJohnson & Johnson; iZiko
lasePaul Ehrlich libabiza ngokuba "ziintsholongwane

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zofuzo") kunomngcipheko onyukileyo womhlaza na.

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Iziphumo bezothusa: (phakathi kwezinye izinto) umngcipheko
wonyuswa kakhulu nge-54% wokulaliswa esibhedlele

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ngenxa yomhlaza wamabele kunye nomngcipheko wonke
owonyuswe nge-23% wokulaliswa esibhedlele ngenxa yomhlaza.

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Oku kuthetha ukuthi, umzekelo, omnye kwabathathu abafazi
abafunyaniswe benomhlaza wamabele uchaphazeleke ngenxa nje

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yokuba efumene isitofu esinye okanye ngaphezulu sejenetiki.

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Lilonke, kwabantu abahlanu abachaphazelwe
yimhlaza abagonyiweyo, omnye uyisixhoba

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00:05:05,616 --> 00:05:11,190
sokugonywa kwangaphambili, kungakhathaliseki isini.

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Isishwankathelo solu phononongo sinokufunyanwa kwincwadi
yam ethi "GEPRÜFT & BESTÄTIGT" (Eviviniweyo Nokuqinisekiswa),

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, kumaphepha 170 ukuya ku-172, efakwe kunye neleta le.

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Ungabona kwi-Appendix 2 edityaniswe apha ukuba
uphando lwasePescara luqinile ngokwendlela olwenziwe ngayo.

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00:05:34,250 --> 00:05:43,476
Ukongeza, uphando lwe-retrospective cohort oluvela eMzantsi Korea
lwapapashwa ngomhla wama-24 kuSeptemba 2024, lusekelwe kwidatha

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evela kubantu abazizigidi eziyi-8.4 baseMzantsi Korea abanepolisi
ye-inshorensi yezempilo, luqinisekisa iziphumo zophando

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00:05:52,130 --> 00:05:57,708
lwasePescara kunye nokwahluka kamanani
okwalindelwe ngenxa yeendlela zokuphila

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00:05:57,708 --> 00:06:01,803
ezahlukeneyo kunye nejini ekhethekileyo yelizwe.

54
00:06:01,803 --> 00:06:07,876
Iinkcukacha zophononongo lwaseKorea zifumaneka kwiSihlomelo 3.

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00:06:07,876 --> 00:06:14,243
Ngokoluvo lwam, akukaze kubekho izifundo ezisekelwe kangaka
ezithembekileyo malunga neziphumo ebezingalindelekanga

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zamachiza, kwaye akukaze kwenzeke ngaphambili ukuba
isabelo esiphezulu kangaka sabantu sithinteke eJamani.

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Nangona kunjalo, iPaul Ehrlich Institute ayizifezekisi
iimbopheleleko zayo zomthetho zokuthatha amanyathelo.

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Uza kufumana iinkcukacha ezipheleleyo malunga noxanduva
oluhambelanayo lwePaul Ehrlich Institute

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kwincwadi yam ethi "GEPRÜFT & BESTÄTIGT" , ,
kumaphepha ama-56 ukuya kuma-73, efakwe kunale leta.

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Ukongeza kwizifundo zasePescara naseKorea, enye inkcukacha-ntetho
ebalulekileyo ephononongwe ngoogxa yaphapashwa ngomhla we-6

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kuSeptemba (Speicher et al. 2025) yapapashwa ngomhla we-6
kuSeptemba, ebonisa ngobubanzi nobunzulu obuchukumisayo oko

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kwakusele kupapashiwe izihlandlo ezininzi ngendlela elula
enovavanyo lwontanga, okoko kukuthi izitofu

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zokugonya ze-mRNA zingcoliswe kakhulu yi-DNA,
ethwele umngcipheko wemfezeko ngokwayo (Isihlomelo 5).

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Isishwankathelo sophando lukaSpeicher et al. 2025
sinokufunyanwa kwincwadi yam ethi "GEPRÜFT &

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BESTÄTIGT" , engekwe kule leta, kumaphepha 159 ukuya ku-162.

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Njengoko kucacisiwe kwi-Appendix 5, ngokubanzi kuyavakala ukuba
ungcoliseko olukhulu lwe-DNA kwi-mRNA

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yee-vaccine luyimbangela yomngcipheko omnyukileyo
womhlaza ofunyenwe kuphando lwasePescara naseKorea.

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Nangona kunjalo, i-SV40 promoter enhancer, ekhoyo ngobuninzi
obukhulu njengongcoliseko lwe-DNA kwi-Comirnaty,

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kunokwenzeka ukuba idlale indima ngokukodwa ngenxa
yeengozi zayo ezithile zokubangela umhlaza ebantwini.

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Iinkcukacha ezipheleleyo malunga
nomngcipheko womhlaza obangelwa yi-SV40 promoter

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enhancer kwi-Comirnaty zifumaneka kwi-Appendix 4.

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Ngenxa yezi meko, ngale ndlela ndifaka isikhalazo sobugcisa
ngabasebenzi abanoxanduva bePaul Ehrlich

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Institute, abasilele iinyanga ngoku ukunika uphando
lwasePescara isimo esisemthethweni esifaneleyo.

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Kucacile ukuba kukho ingozi esondelayo, ingakumbi ngokumalunga
neegonyo ze-mRNA, ngokwentsingiselo yesoyikiso esibi kakhulu

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nesingazange sibonwe kwimpilo yoluntu ngenxa yeziphumo
ebezingalindelekanga zamachiza, ngoko ke isenzo esikhawulezileyo

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sokunqumamisa iimvume zezitofu ze-mRNA kuphela ukhetho olukhoyo.

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Emva koko, kufuneka kwenziwe uphando olubanzi ukuze kufunyaniswe
ukuba abantu abagonyiweyo benzakele

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kangakanani, kwaye abo bachaphazelekileyo kufuneka
baziswe ngendlela abanokufumana ngayo imbuyekezo.

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Ngokubhekiselele kuxanduva, ndingathanda ukukhomba ukuba
abavelisi banoxanduva lokungcoliseka kwe-DNA,

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00:09:37,585 --> 00:09:46,316
nangona iRiphabliki yeFederal yaseJamani ithathe uxanduva
lwesivumelwano ngomonzakalo wezinye iyeza lokugonya.

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00:09:46,316 --> 00:09:56,201
Ngokoluvo lwam, iCandelo 314 leMigaqo-sityholo yaseJamani (StGB)
(ukutshabalalisa okubeka uluntu esichengeni) lisebenza

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ngale ndlela, njengoko kunokufundwa kwincwadi yam ekunye nale
"GEPRÜFT & BESTÄTIGT" kumaphepha angama-255 ukuya kuma-261.

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00:10:07,990 --> 00:10:16,331
Ukuba andifumani mpendulo eyanelisayo kuwe ngomhla we-10
kuNovemba 2025, ndigcina ilungelo lokufaka izimangalo

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zolwaphulo-mthetho kunye nezinye izikhalazo
zolawulo ngakubo bonke abantu abaxanduva,

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kuquka nabo basekwigatsha lakho, ukuba kuyimfuneko.

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Kungenjalo, kufuneka wazi nokuba iinkcukacha eziphambili sele
zifumaneka kwisebe elingundoqo leOfisi kaTshansela kwaye ke

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ngoko, eneneni, zikwi-ofisi yabucala kaTshansela. Ozithobileyo,

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Zihlobo ezihloniphekileyo, ndiyanibongoza ukuba nime ngoku,
kungekuphela ngenxa yenu, kodwa nangenxa yabo

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nibathandayo, ngenxa yabantwana bethu, nabazukulwana
bethu, kwaye nize nxase kwaye nincede uMnu. Kirchner.

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Hamba kakuhle! Konke okuhle!