WEBVTT

00:00.335 --> 00:03.403
Isikhalazo sobugxwayiba esichasene nePaul Ehrlich Institute

00:03.403 --> 00:08.953
Ngo-2025, kwapapashwa izifundo ezibini, zombini ezi
zibonise umngcipheko onyuke kakhulu womhlaza emva

00:08.953 --> 00:12.976
kokugonywa ngeentlobo zezijovo ezibizwa ngokuba zii-mRNA.

00:12.976 --> 00:19.026
Emva kokuba iPaul Ehrlich Institute (PEI) enoxanduva ilile
ukuphendula ngexesha elifanelekileyo, ngokuchasene nemimiselo

00:19.026 --> 00:25.570
yomthetho, isazi ngezakhi zophilo nengcali yamachiza uGqr. Jürgen
O. Kirchner ufake isikhalazo sokubeka iliso ngokuchasene ne-PEI.

00:25.570 --> 00:30.324
UGqr. Kirchner ucinga ukuba umngcipheko
womhlaza unokubangelwa lulonakalo lwe-DNA

00:30.324 --> 00:33.870
olufunyenwe kwizincwadi ezininzi ezipapashiweyo.

00:33.870 --> 00:39.013
Ngenxa yobunzulu obukhulu bale nyathelo
kwimpilo yoluntu, uNjingalwazi Gqr. Sucharit

00:39.013 --> 00:42.903
Bhakdi ubongoza inkxaso kaGqr. Kirchner kwividiyo.

00:42.903 --> 00:47.836
Injongo kukuba i-PEI igcwalise
umsebenzi wayo owunyanzeliswe ngumthetho.

00:47.836 --> 00:54.365
NgokukaGqr. Kirchner, abavelisi begonyo abakhululwanga kwityala
ngenxa yongcoliseko lwe-DNA, kodwa banokubekwa ityala

00:54.365 --> 01:03.063
"lokubeka uluntu esichengeni ngokutyhefa" phantsi kweCandelo 314
loMthetho woLwaphulo-mthetho. Ngoku mamela uNjing. Gqr. Bhakdi:

01:07.850 --> 01:16.471
"Manenekazi nobangeni, uGqr. Jürgen Kirchner wenze
inyathelo esilithatha njengelibaluleke kakhulu

01:16.471 --> 01:22.649
kangangokuba singathanda ukwazisa uluntu ngokubanzi ngalo."

01:22.649 --> 01:30.190
Umxholo ongundoqo sisikhalazo sobugosa
esijoliswe kuMphathiswa Nina Warken.

01:30.190 --> 01:34.676
Ndiza kufundela esi sikhalazo sobugcini.

01:34.676 --> 01:38.683
UMnu Kirchner undinike imvume.

01:38.683 --> 01:44.179
Ukusetyenziswa kombhalo kwesikhalazo
sokongamela esincanyathiselwe kwisihlomelo

01:44.179 --> 01:47.876
kuxhomekeke ekuthotyelweni kwezi mfuno zilandelayo:

01:47.876 --> 01:54.456
Okokuqala, ubunobhala bukaMnu. Kirchner kufuneka
bukhankanywe ngokukodwa – nto leyo endiyenzayo ngoku.

01:54.456 --> 02:04.116
Kufuneka kuchazwe ngokucacileyo ukuba umxholo kwisikhalazo
sobugxwayiba uvela kuphando lwakhe njengombhali weencwadi.

02:04.116 --> 02:12.896
Incwadi ekuthethwa ngayo, "Tested and Confirmed", kufuneka
ikhankanywe kwaye nesihloko sayo siboniswe ngokucacileyo.

02:12.896 --> 02:18.763
Umbhalo kwisikhalazo sobugcisa akufuneki utshintshwe.

02:18.763 --> 02:28.602
Okokugqibela, ukuba amaxwebhu adwelelekayo adityaniswe nevidiyo,
kufuneka kuqinisekiswe ukuba inguqulelo yombiko wokhexo

02:28.602 --> 02:34.856
olufakwe njengeNqaku lesi-2 nayo iyafumaneka ngendlela efanayo.

02:34.856 --> 02:43.088
Ukuba le vidiyo ijoliswe kubabukeli abangathethiyo isiJamani,
inguqulelo yesiNgesi yexela-khalazo lokongamela

02:43.088 --> 02:51.170
elinamathiselwe njenge-Appendix 3 kufuneka nayo
ifakwe. Sikwenza oku njengenyathelo lokulumka.

02:51.170 --> 02:59.736
Manenekazi nobangentsi, ngoku ndiza
kufunda ileta eya kuMphathiswa Nina Warken.

02:59.736 --> 03:07.715
Ileta ebhalisiweyo yahanjiswa ngomhla we-12 ku-Okthobha 2025

03:07.715 --> 03:17.498
Ingozi esondelayo: Isikhalazo sobugxwayiba esichasene nabasebenzi
be-Paul Ehrlich Institute abanoxanduva lokuqinisekisa ukuba

03:17.498 --> 03:27.047
izifundo ezibini ezinkulu kakhulu nezisemthethweni ze-cohort
azithathelwa ngqalelo ngendlela emiselweyo ngumthetho malunga

03:27.047 --> 03:37.064
nokhuseleko lwamachiza e-mRNA nezinye izitofu zokugonya ze-gene
ngokubhekiselele kwiingozi ezibalulekileyo zomhlaza, nangona oku

03:37.064 --> 03:43.030
kubeka isisongelo esingazange sibekho kwimpilo yoluntu eJamani.

03:43.030 --> 03:53.568
Mhlekazi uMphathiswa, Ngomhla woku-1 kuJulayi 2025, iNcwadi
yasePescara, uphando lweqela elilindelweyo olunabathathi-nxaxheba

03:53.568 --> 04:02.603
abaphantse babe ngama-300,000 – bonke abahlali bephondo
lase-Itali iPescara abaneminyaka eli-11 nangaphezulu –

04:02.603 --> 04:08.253
yapapashwa njengopapasho lwenzululwazi oluhlolwe ngoontanga.

04:08.253 --> 04:15.452
Uphando luye lwaphonononga ukuba ingaba ukugonywa
ngeentsholongwane zofuzo ze-COVID-19 (iBioNTech, iModerna,

04:15.452 --> 04:21.917
iAstraZeneca kunye neJohnson & Johnson; iZiko
lasePaul Ehrlich libabiza ngokuba "ziintsholongwane

04:21.917 --> 04:25.743
zofuzo") kunomngcipheko onyukileyo womhlaza na.

04:25.743 --> 04:34.967
Iziphumo bezothusa: (phakathi kwezinye izinto) umngcipheko
wonyuswa kakhulu nge-54% wokulaliswa esibhedlele

04:34.967 --> 04:45.176
ngenxa yomhlaza wamabele kunye nomngcipheko wonke
owonyuswe nge-23% wokulaliswa esibhedlele ngenxa yomhlaza.

04:45.176 --> 04:53.156
Oku kuthetha ukuthi, umzekelo, omnye kwabathathu abafazi
abafunyaniswe benomhlaza wamabele uchaphazeleke ngenxa nje

04:53.156 --> 04:58.350
yokuba efumene isitofu esinye okanye ngaphezulu sejenetiki.

04:58.350 --> 05:05.616
Lilonke, kwabantu abahlanu abachaphazelwe
yimhlaza abagonyiweyo, omnye uyisixhoba

05:05.616 --> 05:11.190
sokugonywa kwangaphambili, kungakhathaliseki isini.

05:11.190 --> 05:20.266
Isishwankathelo solu phononongo sinokufunyanwa kwincwadi
yam ethi "GEPRÜFT & BESTÄTIGT" (Eviviniweyo Nokuqinisekiswa),

05:20.266 --> 05:25.250
, kumaphepha 170 ukuya ku-172, efakwe kunye neleta le.

05:25.250 --> 05:34.250
Ungabona kwi-Appendix 2 edityaniswe apha ukuba
uphando lwasePescara luqinile ngokwendlela olwenziwe ngayo.

05:34.250 --> 05:43.476
Ukongeza, uphando lwe-retrospective cohort oluvela eMzantsi Korea
lwapapashwa ngomhla wama-24 kuSeptemba 2024, lusekelwe kwidatha

05:43.476 --> 05:52.130
evela kubantu abazizigidi eziyi-8.4 baseMzantsi Korea abanepolisi
ye-inshorensi yezempilo, luqinisekisa iziphumo zophando

05:52.130 --> 05:57.708
lwasePescara kunye nokwahluka kamanani
okwalindelwe ngenxa yeendlela zokuphila

05:57.708 --> 06:01.803
ezahlukeneyo kunye nejini ekhethekileyo yelizwe.

06:01.803 --> 06:07.876
Iinkcukacha zophononongo lwaseKorea zifumaneka kwiSihlomelo 3.

06:07.876 --> 06:14.243
Ngokoluvo lwam, akukaze kubekho izifundo ezisekelwe kangaka
ezithembekileyo malunga neziphumo ebezingalindelekanga

06:14.243 --> 06:20.910
zamachiza, kwaye akukaze kwenzeke ngaphambili ukuba
isabelo esiphezulu kangaka sabantu sithinteke eJamani.

06:20.910 --> 06:29.083
Nangona kunjalo, iPaul Ehrlich Institute ayizifezekisi
iimbopheleleko zayo zomthetho zokuthatha amanyathelo.

06:29.083 --> 06:37.427
Uza kufumana iinkcukacha ezipheleleyo malunga noxanduva
oluhambelanayo lwePaul Ehrlich Institute

06:37.427 --> 06:46.416
kwincwadi yam ethi "GEPRÜFT & BESTÄTIGT" , ,
kumaphepha ama-56 ukuya kuma-73, efakwe kunale leta.

06:46.416 --> 06:56.252
Ukongeza kwizifundo zasePescara naseKorea, enye inkcukacha-ntetho
ebalulekileyo ephononongwe ngoogxa yaphapashwa ngomhla we-6

06:56.252 --> 07:05.458
kuSeptemba (Speicher et al. 2025) yapapashwa ngomhla we-6
kuSeptemba, ebonisa ngobubanzi nobunzulu obuchukumisayo oko

07:05.458 --> 07:13.405
kwakusele kupapashiwe izihlandlo ezininzi ngendlela elula
enovavanyo lwontanga, okoko kukuthi izitofu

07:13.405 --> 07:22.343
zokugonya ze-mRNA zingcoliswe kakhulu yi-DNA,
ethwele umngcipheko wemfezeko ngokwayo (Isihlomelo 5).

07:22.343 --> 07:31.359
Isishwankathelo sophando lukaSpeicher et al. 2025
sinokufunyanwa kwincwadi yam ethi "GEPRÜFT &

07:31.359 --> 07:38.130
BESTÄTIGT" , engekwe kule leta, kumaphepha 159 ukuya ku-162.

07:38.130 --> 07:46.810
Njengoko kucacisiwe kwi-Appendix 5, ngokubanzi kuyavakala ukuba
ungcoliseko olukhulu lwe-DNA kwi-mRNA

07:46.810 --> 07:56.563
yee-vaccine luyimbangela yomngcipheko omnyukileyo
womhlaza ofunyenwe kuphando lwasePescara naseKorea.

07:56.563 --> 08:06.241
Nangona kunjalo, i-SV40 promoter enhancer, ekhoyo ngobuninzi
obukhulu njengongcoliseko lwe-DNA kwi-Comirnaty,

08:06.241 --> 08:16.203
kunokwenzeka ukuba idlale indima ngokukodwa ngenxa
yeengozi zayo ezithile zokubangela umhlaza ebantwini.

08:16.203 --> 08:22.646
Iinkcukacha ezipheleleyo malunga
nomngcipheko womhlaza obangelwa yi-SV40 promoter

08:22.646 --> 08:28.043
enhancer kwi-Comirnaty zifumaneka kwi-Appendix 4.

08:28.043 --> 08:37.266
Ngenxa yezi meko, ngale ndlela ndifaka isikhalazo sobugcisa
ngabasebenzi abanoxanduva bePaul Ehrlich

08:37.266 --> 08:46.656
Institute, abasilele iinyanga ngoku ukunika uphando
lwasePescara isimo esisemthethweni esifaneleyo.

08:46.656 --> 08:58.658
Kucacile ukuba kukho ingozi esondelayo, ingakumbi ngokumalunga
neegonyo ze-mRNA, ngokwentsingiselo yesoyikiso esibi kakhulu

08:58.658 --> 09:10.270
nesingazange sibonwe kwimpilo yoluntu ngenxa yeziphumo
ebezingalindelekanga zamachiza, ngoko ke isenzo esikhawulezileyo

09:10.270 --> 09:17.303
sokunqumamisa iimvume zezitofu ze-mRNA kuphela ukhetho olukhoyo.

09:17.303 --> 09:23.270
Emva koko, kufuneka kwenziwe uphando olubanzi ukuze kufunyaniswe
ukuba abantu abagonyiweyo benzakele

09:23.270 --> 09:30.144
kangakanani, kwaye abo bachaphazelekileyo kufuneka
baziswe ngendlela abanokufumana ngayo imbuyekezo.

09:30.144 --> 09:37.585
Ngokubhekiselele kuxanduva, ndingathanda ukukhomba ukuba
abavelisi banoxanduva lokungcoliseka kwe-DNA,

09:37.585 --> 09:46.316
nangona iRiphabliki yeFederal yaseJamani ithathe uxanduva
lwesivumelwano ngomonzakalo wezinye iyeza lokugonya.

09:46.316 --> 09:56.201
Ngokoluvo lwam, iCandelo 314 leMigaqo-sityholo yaseJamani (StGB)
(ukutshabalalisa okubeka uluntu esichengeni) lisebenza

09:56.201 --> 10:07.990
ngale ndlela, njengoko kunokufundwa kwincwadi yam ekunye nale
"GEPRÜFT & BESTÄTIGT" kumaphepha angama-255 ukuya kuma-261.

10:07.990 --> 10:16.331
Ukuba andifumani mpendulo eyanelisayo kuwe ngomhla we-10
kuNovemba 2025, ndigcina ilungelo lokufaka izimangalo

10:16.331 --> 10:22.777
zolwaphulo-mthetho kunye nezinye izikhalazo
zolawulo ngakubo bonke abantu abaxanduva,

10:22.777 --> 10:27.584
kuquka nabo basekwigatsha lakho, ukuba kuyimfuneko.

10:27.584 --> 10:38.413
Kungenjalo, kufuneka wazi nokuba iinkcukacha eziphambili sele
zifumaneka kwisebe elingundoqo leOfisi kaTshansela kwaye ke

10:38.413 --> 10:44.703
ngoko, eneneni, zikwi-ofisi yabucala kaTshansela. Ozithobileyo,

10:44.703 --> 10:55.094
Zihlobo ezihloniphekileyo, ndiyanibongoza ukuba nime ngoku,
kungekuphela ngenxa yenu, kodwa nangenxa yabo

10:55.094 --> 11:07.656
nibathandayo, ngenxa yabantwana bethu, nabazukulwana
bethu, kwaye nize nxase kwaye nincede uMnu. Kirchner.

11:07.656 --> 11:11.496
Hamba kakuhle! Konke okuhle!