WEBVTT

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Isikhalazo sobuholi esibhekiswe ePaul Ehrlich Institute

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Ngo-2025 kwashicilelwa izifundo ezimbili, zombili
ezavezisa ingozi enkulu kakhulu yomdlavuza

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kulandela ukugonywa ngemijovo ebizwa ngokuthi i-mRNA.

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Ngemva kokuthi i-Paul Ehrlich Institute (PEI) enesibopho
yehlulekile ukuphendula ngesikhathi esifanele, ngokuphikisana

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nezimfuneko zomthetho, isazi sezinto eziphilayo
nochwepheshe wezokwelapha uDkt. Jürgen O. Kirchner

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wafaka isikhalazo sokwengamela ngokumelene ne-PEI.

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UDkt. Kirchner ucabanga ukuthi ingozi yomdlavuza
ibangelwa ukungcola kwe-DNA okutholakale emibhalweni eminingana.

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Ngenxa yokubaluleka okukhulu kwalesi sinyathelo
empilweni yomphakathi, uProfesa uDkt. Sucharit

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Bhakdi ubiza ukwesekwa kukaDkt. Kirchner kuvidiyo.

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Inhloso ukuthi i-PEI igcwalise umsebenzi wayo osemthethweni.

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NgokukaDkt. Kirchner, abakhiqizi bemithi yokugoma abakhululekile
emthwalweni wemfanelo ngenxa yokungcoliswa kwe-DNA, kodwa

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bangabekwa icala lokubeka umphakathi engozini
ngokuthelisa ngaphansi kwesigaba 314 soMthetho

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Wezobugebengu. Manje lalela uProfesa Dkt. Bhakdi:

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"Bafazi nabesilisa, uDkt. Jürgen Kirchner
wenze isinyathelo esibaluleke kithi kangangokuba

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sifuna ukwazisa umphakathi wonke ngalolu lwazi."

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Okuqukethwe okuyinhloko kuyikhalazo
lokwengamela ebhalwe kuNgqongqoshe uNina Warken.

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Ngizofunda lokhu kukhalaza kokugadela.

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UMnu. Kirchner ungiphe imvume.

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Ukusetshenziswa kombhalo kwesikhalazo sokwengamela okunamathiselwe
esihlomulweni kuncike ekulandeleni lezi zidingo ezilandelayo:

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Okokuqala, ubunikazi bokubhala bukaMnu. Kirchner
kumele buphawulwe ngokukhethekile – engikwenzayo lapha.

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Kufanele kuchazwe ngokusobala ukuthi okuqukethwe kwesikhalazo
sokwengamela kuvela ocwaningweni lwakhe njengombhali wencwadi.

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Incwadi ekhulunywa ngayo, ethi "Tested and Confirmed", kufanele
ikhulunywe ngayo futhi isihloko sayo siboniswe ngokusobala.

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Umbhalo wesikhalazo sokwengamela akufanele ushintshwe.

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Ekugcineni, uma imibhalo engalandwa ifakwe kuvidiyo,
kumele kuqinisekiswe ukuthi inguqulo yokhalazo lokwengamela

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efakwe njengeSihlomelo 2 nayo iyatholakala ngendlela efanayo.

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Uma ividiyo ihloselwe ababukeli abangakhulumi isiJalimane,
inguqulo yesiNgisi yokhalazo lokwengamela

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elinamathiselwe njengeSihlomelo 3 nayo kumele
ifakwe. Senza lokhu njengenyathelo lokuqapha.

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Bafazi nabesilisa, manje ngizofunda
incwadi kuNgqongqoshe uNina Warken.

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Incwadi ebhalisiwe yahanjiswa ngomhlaka 12 Okthoba 2025

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Ingozi esondelene: Isikhalazo sobuholi esibhekiswe kubasebenzi
be-Paul Ehrlich Institute abaphethe ukuqinisekisa ukuthi izifundo

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ezimbili ezinkulu kakhulu nezisemthethweni ze-cohort
azicatshangelwa ngendlela ebekwe ngumthetho maqondana nokuphepha

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kwemithi ye-mRNA nezinye izitofu zokugoma ze-gene
mayelana nezingozi ezinkulu zomdlavuza, nakuba lokhu kubeka

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insongo engakaze ibonwe kwezempilo yomphakathi eJalimane.

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Mhlonishwa uNgqongqoshe, Ngo-1 Julayi 2025, i-Pescara Study,
ucwaningo lweqoqo oluzayo olubandakanya cishe abahlanganyeli

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abangama-300 000 – bonke abahlali besifunda
sase-Italy i-Pescara abaneminyaka engu-11 nangaphezulu –

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yashicilelwa njengomsebenzi wesayensi ohlolewe ngontanga.

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Ucwaningo luhlolisise ukuthi ngabe ukugonywa ngemijovo
yemfivuzane ye-COVID-19 (BioNTech, Moderna, AstraZeneca kanye

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neJohnson & Johnson; iPaul Ehrlich Institute ibiza le mijovo
ngokuthi "imijovo yofuzo") kuhilela ingozi eyandisiwe yomdlavuza.

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Imiphumela yayethusa: (phakathi kwezinye izinto) ingozi yokungena
esibhedlela ngenxa yomdlavuza wamabele

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yakhuphuka ngo-54%, kanti ingozi iyonke yokungena
esibhedlela ngenxa yomdlavuza yakhuphuka ngo-23%.

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Lokhu kusho ukuthi, isibonelo, owesifazane oyedwa
kwabathathu abatholakele bene-mhlaza wamabele uthinteka kuphela

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ngoba wamukele umjovo owodwa noma ngaphezulu wemfiva yegene.

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Sekukonke, kwabantu abahlanu abathintekile umdlavuza
abavele begonyelwe, munye ungumuntu ohluphekile ngenxa

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yokugonywa kwangaphambilini, kungakhathalekile ubulili.

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Isifinyezo salolu cwaningo singatholakala encwadini
yami ethi "GEPRÜFT & BESTÄTIGT" (Ehlolwe Futhi Kuqinisekisiwe),

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, kumakhasi 170 kuya ku-172, efakwe kule ncwadi.

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Ungabona ku-Appendix 2 ehlanganisiwe lapha ukuthi
ucwaningo lwasePescara luhambisana nezindlela zocwaningo.

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Ngaphezu kwalokho, ucwaningo lwe-cohort olubuyekeziwe oluvela
eNingizimu Korea lwashicilelwa ngomhlaka 24 Septhemba 2024,

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lusekelwe kudatha yabantu abayizigidi eziyi-8.4 abanepholisi
lomshwalense wezempilo eNingizimu Korea, luqinisekisa imiphumela

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yocwaningo lwasePescara ngokwehluka kwezibalo
okulindelekile ngenxa yezindlela zokuphila

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ezihlukene kanye nezici zezakhi zofuzo ezihlukile zezwe.

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Imininingwane yocwaningo
lwaseKorea ingatholakala ku-Isihlomelo 3.

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Ngokombono wami, akukaze kube nocwaningo lwamaqoqo olusekelwe
kahle kangaka mayelana nemiphumela engemihle

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yemithi, futhi akukaze kube khona ngaphambili ukuthi
ingxenye enkulu kangaka yabantu eJalimane ithinteke.

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Noma kunjalo, i-Paul Ehrlich Institute
ayigcwalisi isibopho sayo somthetho sokuthatha izinyathelo.

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Uzothola imininingwane eningiliziwe mayelana nesibopho esifanele
sePaul Ehrlich Institute encwadini yami ethi "GEPRÜFT &

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BESTÄTIGT" , , efakwe kule ncwadi, kumakhasi 56 kuya ku-73.

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Ngaphezu kocwaningo lwasePescara nolwaseKorea, olunye ucwaningo
olubalulekile oluhlolwe ngontanga lwashicilelwa ngomhlaka 6

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Septhemba (Speicher et al. 2025) yashicilelwa ngomhlaka 6
Septhemba, ekhombisa ngobubanzi nangokujula okumangalisayo lokho

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okwakuseshicilelwe kaningi ngendlela elula ngemva
kokubuyekezwa ngontanga, okungukuthi imijovo ye-mRNA ingcolile

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kakhulu nge-DNA, ethwala ingozi yomdlavuza (Isihlomelo 5).

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Isifinyezo socwaningo luka-Speicher et al. sango-2025
sitholakala encwadini yami ethi "GEPRÜFT &

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BESTÄTIGT" , exhunyiwe kule ncwadi, kumakhasi 159 kuya ku-162.

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Njengoba kuchazwe ku-Appendix 5, kuvamile ukuthi ukungcola
okukhulu kwe-DNA emajabeni e-mRNA kubangele ukwanda kwengozi

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yomdlavuza okutholakele ocwaningweni lwasePescara naseKorea.

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Nokho, i-enhancer ye-promoter ye-SV40, etholakala ngobuningi
obukhulu njengongcoliswa we-DNA ku-Comirnaty,

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kungenzeka idlale indima ikakhulukazi ngenxa
yengozi yayo ethile yokubangela umdlavuza kubantu.

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Ulwazi olunemininingwane ngengozi yomdlavuza ebangelwa yi-enhancer
ye-promoter ye-SV40 ku-Comirnaty lutholakala ku-Appendix 4.

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Ngokubheka lezi zimo, ngalokhu ngifaka isikhalazo sokwengamela
kubasebenzi abaphethe ePaul Ehrlich Institute,

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abahlulekile izinyanga manje ukunikeza
ucwaningo lwasePescara isimo esisemthethweni esifanele.

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Kuyabonakala ukuthi kunengozi esondeleneyo, ikakhulukazi
maqondana nemijovo ye-mRNA, ngokomqondo wesongo esinzima kakhulu

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futhi esingakaze sibe khona empilweni yomphakathi ngenxa
yemiphumela engemihle yemithi, ngakho-ke isinyathelo esiphuthumayo

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sokumiswa kwezimvume zokugonywa kwe-mRNA kuyindlela kuphela.

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Emva kwalokho, kumele kwenziwe uphenyo oluphelele ukuze
kutholakale ukuthi abantu abagonyiwe balimele

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kangakanani, futhi labo abathintekile kumele baziswe
ukuthi bangathola kanjani ukulungiswa noma inkokhelo.

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Mayelana nezibopho, ngithanda ukukhombisa ukuthi abakhiqizi
banesibopho sokungcoliswa kwe-DNA, nakuba

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iRiphabhulikhi Yezwe yaseJalimane ithathe isibopho
senkontileka ngokulimala okunye okuvela kwemijovo yokugoma.

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Ngokombono wami, Isigaba 314 soMthetho Wezobugebengu waseJalimane
(StGB) (ukubulala ngobuthi okuyingozi emphakathini) sisebenza

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ngale ndlela, njengoba kungafundwa encwadini yami ebhalwe
ngokuthi "GEPRÜFT & BESTÄTIGT" kumakhasi 255 kuya ku-261.

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Uma ngingatholi impendulo eyanelisayo kuwe ngo-10 Novemba 2025,
ngigodla ilungelo lokufaka izinsolo zobugebengu nokwenza

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eminye imikhalo yokwengamela kubo bonke abanesibopho,
kuhlanganise nalabo abasemnyangweni wakho, uma kudingeka.

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Ngaphandle kwalokho, kufanele futhi wazi ukuthi imininingwane
ebalulekile isivele itholakala emnyangweni ophakathi

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weHhovisi likaChancellor, ngaleyo ndlela, empeleni,
ifinyelela ehhovisi langasese likaChancellor. Ngokwethembeka,

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Bafazi nabesilisa, ngiyanibiza ukuthi nimile manje, hhayi nina
kuphela, kodwa nabathandekayo benu, ezinganeni zethu, ezingane

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zethu ezincane, futhi nisekele futhi nisize uMnu. Kirchner.

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Hala! Ngikufisela konke okuhle!